A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan

Authors:	Tsukasa Okamoto Yasunari Miyazaki Takashi Ogura Kingo Chida Nobuoki Kohno Shigeru Kohno Hiroyuki Taniguchi Shinobu Akagawa Yoshiro Mochizuki Kohei Yamauchi Hiroki Takahashi Takeshi Johkoh Sakae Homma Kazuma Kishi Soichiro Ikushima Satoshi Konno Michiaki Mishima Ken Ohta Naohiko Inase

Affiliation:	1. Department of Integrated Pulmonology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;2. Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1, Tomiokahigashi, Kanagawa-ku, Yokohama City, Kanagawa 236-0051, Japan;3. Department of Respiratory Medicine, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu City, Shizuoka 431-3192, Japan;4. Department of Molecular and Internal Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan;5. Second Department of Internal Medicine, Nagasaki University, 1-7-1, Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan;6. Department of Respiratory Medicine and Allergy, Tosei General Hospital, 160-Banchi, Nishioiwake, Seto City, Aichi 489-8642, Japan;7. Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital, 3-1-1, Takeoka, Kiyose City, Tokyo 204-8585, Japan;8. Department of Internal Medicine, Himeji Medical Center, 68-Banchi, Honnmachi, Himeji City, Hyogo 670-8520, Japan;9. Department of Internal Medicine, Iwate Medical University, 19-1, Maruuchi, Morioka City, Iwate 020-8505, Japan;10. Department of Internal Medicine, Sapporo Medical University, 16-291, Minamiichijo-nishi, Chuo-ku, Sapporo City, Hokkaido 060-8543, Japan;11. Department of Radiology, Kinki Central Hospital, 3-1, Kurumazuka, Itami City, Hyogo 664-8533, Japan;12. Department of Respiratory Medicine, Toho University, 6-11-1, Omori-nishi, Ota-ku, Tokyo 143-8541, Japan;13. Department of Respiratory Medicine, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo 105-8470, Japan;14. Department of Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22, Hiroo, Shibuya-ku, Tokyo 150-8935, Japan;15. First Department of Medicine, Hokkaido University, 5-chome, Kita14-Jo-Nishi, Kita-ku, Sapporo City, Hokkaido 060-8648, Japan;p. Department of Respiratory Medicine, Kyoto University, 54-banchi, Kawara-cho, Seigoinn, Sakyo-ku, Kyoto City, Kyoto 606-8507, Japan;q. Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan;r. Department of Respiratory Medicine, Tokushima University, 2-50-1, Kuramoto-cho, Tokushima City, Tokushima 770-8503, Japan;s. Department of Respiratory Medicine, Hiratsuka Kyosai Hospital, 9-11, Oiwake, Hiratsuka City, Kanagawa 254-8502, Japan;t. Department of Pulmonary Medicine, Fukushima Medical University, 1-banchi, Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan;u. Department of Respiratory Medicine, Fukuoka University, 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka 814-0180, Japan;v. Department of Respiratory Medicine, Yamanashi Prefectural Central Hospital, 1-1-1, Fujimi, Kofu City, Yamanashi 400-8506, Japan;1. Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-0012, Japan;2. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan;1. Department of Surgery 1, Fukushima Medical University, Fukushima, Japan;2. Institute of Advanced Biomedical Engineering and Science, Tokyo Women''s Medical University, Tokyo, Japan;1. Japan Society for Transplantation, Japan;2. Division of Urology Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan;3. Department of Advanced Technology for Transplantation, Osaka University, Osaka, Japan;4. Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Tochigi, Japan;5. Department of Medical Informatics / Center for Information, Jichi Medical University, Tochigi, Japan;1. Department of Respiratory Medicine, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan;2. Department of General Thoracic Surgery, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan;3. Department of General Medicine, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan;4. Department of Diagnostic Pathology, Kanto-Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki City, Kanagawa Prefecture, Japan;1. Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan;2. Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

Abstract:	BackgroundIn 1999, a Japanese epidemiological survey of chronic hypersensitivity pneumonitis (HP) showed that summer-type HP was the most prevalent variant of the disease. The number of reported cases of chronic HP has recently been increasing, and the clinical features of the disease seem to have changed. We conducted another nationwide epidemiological survey of chronic HP in Japan to determine better estimates of the frequency and clinical features of the disease.MethodsA questionnaire was sent to qualified hospitals throughout Japan, and data on cases of chronic HP diagnosed between 2000 and 2009 were collected.ResultsIn total, 222 cases of chronic HP from 22 hospitals were studied. Disease subtypes included bird-related HP (n=134), summer-type HP (n=33), home-related HP (n=25), farmer's lung (n=4), isocyanate-induced HP (n=3), and other types (n=23). The median proportion of lymphocytes in bronchoalveolar lavage fluid was high (24.5%). The primary findings of computed tomography of the chest were ground-glass attenuation and interlobular septal thickening. Centrilobular fibrosis was the major pathological finding on examination of surgical lung biopsy specimens from 93 patients. The median survival time was 83 months.ConclusionsThe proportion of bird-related HP was higher than that in the previous epidemiological survey, and the proportions of isocyanate-induced HP and farmer's lung were lower. A crucial step in diagnosing chronic HP is to thoroughly explore the possibility of antigen exposure.

Keywords:	Hypersensitivity pneumonitis Extrinsic allergic alveolitis Pulmonary fibrosis Surveillance
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏