|
|||||
|
|
| 破骨细胞融合分子机制的研究进展 | |
| 引用本文： | 杨文杰,李耀玺 段莉 王大平. 破骨细胞融合分子机制的研究进展[J]. 生物骨科材料与临床研究, 2020, 17(1): 67-70 |
| 作者姓名： | 杨文杰 李耀玺 段莉 王大平 |
| 作者单位： | 汕头大学医学院;深圳市组织工程重点实验室 |
| 基金项目： | 国家自然科学基金（81772394）;深圳市科技计划项目（JCYJ20170306092215436) |
| 摘 要： | 破骨细胞是体内介导骨吸收的主要细胞。破骨细胞融合过程包括:识别、半融合结构及融合孔形成,最后融合孔扩张、细胞内容物混合。破骨细胞融合与破骨细胞的大小及其骨吸收能力密切相关,对破骨细胞融合分子机制的研究可为骨吸收亢进性疾病的治疗寻求新的突破口。本文就国内外破骨细胞融合过程及其分子机制的最新研究进展进行综述。 |
| 关 键 词： | 破骨细胞 细胞融合 分子机制 |
Advances in molecular mechanism of osteoclasts fusion |
|
| Yang Wenjie,Li Yaoxi,Duan Li,Wang Daping,.. Advances in molecular mechanism of osteoclasts fusion[J]. Orthopaedic Biomechanics Materials and Clinical Study, 2020, 17(1): 67-70 | |
| Authors: | Yang Wenjie Li Yaoxi Duan Li Wang Daping . |
| Affiliation: | (Shantou University Medical College,Shantou Guangdong,515000;Shenzhen Key Laboratory of Tissue Engineering,Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology,Shenzhen Second People's Hospital(The First Affiliated Hospital of Shenzhen University),Shenzhen Guangdong,518035,China) |
| Abstract: | Osteoclasts are the main cells that mediate bone resorption in vivo. The process of osteoclasts fusion include the recognition and formation of hemifusion structure and fusion pore. Finally, the fusion pore expands and the cell contents mixed. Osteoclasts fusion are closely related to their size and bone resorption capacity. Research on the molecular mechanism of osteoclasts fusion can seek new breakthroughs in the treatment of bone resorption aggressive diseases. This review summarizes recent advances in the process of osteoclasts fusion and their molecular mechanisms in our state and abroad. |
| Keywords: | Osteoclast Cell fusion Molecular mechanism |
| 本文献已被 CNKI 维普 等数据库收录！ | |
| 点击此处可从《生物骨科材料与临床研究》浏览原始摘要信息 | |
| 点击此处可从《生物骨科材料与临床研究》下载免费的PDF全文 | |