| 罗库溴铵单次给药在开颅听神经瘤切除术中的临床应用 |
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| 引用本文： | 余琼,姚越,黄翔,许耿,钟平,梁伟民.罗库溴铵单次给药在开颅听神经瘤切除术中的临床应用[J].中国临床神经科学,2019(2):162-168. |
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| 作者姓名： | 余琼 姚越 黄翔 许耿 钟平 梁伟民 |
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| 作者单位： | 复旦大学附属华山医院麻醉科;复旦大学附属华山医院神经外科 |
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| 摘 要： | 目的探讨全凭静脉麻醉下开颅听神经瘤切除术中肌松药罗库溴铵最佳单次给药剂量,在满足全身麻醉诱导气管插管的同时,尽快实现无肌松干扰的面神经功能的精准监测。方法本研究为随机对照开盲的临床试验。将28例择期行开颅听神经瘤切除术的患者随机分为两组(每组14例),静脉单次给予罗库溴铵0.3 mg·kg-1(R0.3)组和罗库溴铵0.6 mg·kg-1(R0.6)组。采用4个成串刺激(TOF)监测两组患者肌松药起效(TOF计数)和消除(TOF比值)情况,并记录气管插管时血压、心率、声门暴露(Cormack-Lehane喉镜显露分级)、气管插管(Cooper评分)情况和插管尝试次数。结果①气管插管时,R0.6组肌松效果优于R0.3组,R_(0.3组7例(50%和R0.6组14例(100%)患者达到中深度肌松(TOF计数为0～2,P=0. 004)。②两组患者Cormack-Lehane分级和Cooper评分均差异无显著性,所有患者气管插管均一次成功。R0.3组和R0.6组的罗库溴铵剂量均能满足气管插管的肌松要求。③R0.3组与R0.6组比较,肌松药消除加快,TOF比值恢复至90%(TTOF 90%)所需时间显著减少(P<0.0001)。结论在丙泊酚-瑞芬太尼全凭静脉麻醉下,单次静脉给药罗库溴铵0.3 mg·kg-1 (理想体重)能满足气管插管的肌松要求,可加快获取面神经监测的术前基线值,有助于听神经瘤切除术中面神经功能的精准监测。
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| 关 键 词： | 罗库溴铵 听神经瘤 面神经功能监测 4个成串刺激 |
Administration of the Single-dose Rocuronium in Patients Undergoing Craniotomy for Acoustic Neuroma Resection |
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| YU Qiong,YAO Yue,HUANG Xiang,XU Geng,ZHONG Ping,LIANG Weimin.Administration of the Single-dose Rocuronium in Patients Undergoing Craniotomy for Acoustic Neuroma Resection[J].Chinese Journal of Clinical Neurosciences,2019(2):162-168. |
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| Authors: | YU Qiong YAO Yue HUANG Xiang XU Geng ZHONG Ping LIANG Weimin |
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| Institution: | (Department of Anesthesiology , Huashan Hospital, Fudan University, Shanghai 200040 , China;Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China) |
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| Abstract: | YU Qiong;YAO Yue;HUANG Xiang;XU Geng;ZHONG Ping;LIANG Weimin(Department of Anesthesiology , Huashan Hospital, Fudan University, Shanghai 200040 , China;Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China) |
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| Keywords: | rocuronium acoustic neuroma facial nerve function monitoring train-of-four stimulation |
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