| 肿瘤微环境与前列腺癌骨转移研究进展 |
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| 引用本文： | 蒙杰,卢奕,张健. 肿瘤微环境与前列腺癌骨转移研究进展[J]. 肿瘤防治研究, 2018, 45(8): 593-597. DOI: 10.3971/j.issn.1000-8578.2018.18.0167 |
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| 作者姓名： | 蒙杰 卢奕 张健 |
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| 作者单位： | 1. 530021 南宁，长寿与老年相关疾病教育部重点实验室，广西医科大学；2. 545005 柳州， 广西医科大学第四附属医院医学检验科；3. 518055 深圳，南方科技大学生物系和医学院；4. 15232 宾夕法尼亚州匹兹堡，美国匹茨堡大学医学院泌尿系 |
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| 基金项目： | 国家自然科学基金重点项目（81130046）；国家自然科学基金面上项目（81272415, 81773146）；广西自然科学基金（2013GXNSFEA053004, 2012GXNSFCB053004,2013GXNSFBA019177）；深圳市科技创新计划基金（JCYJ20170412154619484, JCYJ2017030711041760） |
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| 摘 要： | 前列腺癌（prostate cancer, PCa）转移中大约80%是发生骨转移，是造成患者死亡的主要原因。前列腺癌骨转移主要呈现成骨和破骨混合性损伤。然而，诱发肿瘤细胞转移到骨以及引起混合样病变的机制仍不十分清楚。宿主微环境与前列腺癌细胞间的相互作用是其中一个重要原因。本文主要讨论宿主微环境如何影响前列腺癌骨转移各个阶段的发生及其中的机制，探讨多种细胞因子、分泌蛋白、微环境中的免疫细胞、成骨细胞、破骨细胞等分泌的因子在前列腺癌骨转移中的重要作用。
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| 关 键 词： | 前列腺癌 骨转移 肿瘤微环境 分泌因子 |
| 收稿时间： | 2018-02-01 |
Research Progress of Tumor Microenvironment and Prostate Cancer Bone Metastasis |
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| MENG Jie,LU Yi,ZHANG Jian. Research Progress of Tumor Microenvironment and Prostate Cancer Bone Metastasis[J]. Cancer Research on Prevention and Treatment, 2018, 45(8): 593-597. DOI: 10.3971/j.issn.1000-8578.2018.18.0167 |
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| Authors: | MENG Jie LU Yi ZHANG Jian |
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| Affiliation: | 1. Key Laboratory of Longevity and Ageing-related Diseases (Guangxi Medical University), Ministry of Education, Nanning 530021, China; 2. Medical Science Laboratory, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China; 3. Department of Biology & School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China; 4. Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA |
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| Abstract: | The majority of prostate cancer (PCa)-induced deaths is due to the development of metastatic disease, 80% of which is primarily localized in the bone. The types of bone metastasis of PCa are mainly osteoblastic or osteoclastic lesions. What triggers PCa metastasis to the bone and what causes osteoblastic and osteoclast lesions remain unanswered. A major contributor to PCa metastasis is the host microenvironment. Here, we mainly discuss how primary tumor microenvironment affects the occurrence and mechanism of bone metastasis in prostate cancer. The mechanisms and effects of secretory factors, secretory proteins, immune cells, osteoblasts, osteoclasts and other secreted factors on bone metastasis of prostate cancer will be discussed and summarized. |
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| Keywords: | Prostate cancer Bone metastasis Tumor microenvironment Secretion factor R737.25 |
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