妊娠高血压患者免疫反应的表现及其机制

为探讨妊娠高血压患者的免疫耐受情况,选取42例妊娠高血压患者作为观察组,同期住院的50例血压正常的妊娠者作为对照组,对比两组患者白细胞抗原和T淋巴细胞水平,并分析其对免疫反应的影响。结果显示,与对照组比较,观察组舒张压和尿蛋白显著增高,组织白细胞抗原mRNA表达量明显降低,血清白细胞抗原浓度明显降低,T淋巴细胞CD3⁺、CD4⁺和CD8⁺水平均显著升高。结果提示,妊娠高血压患者免疫耐受降低,可能与妊娠高血压患者体内白细胞抗原降低,T淋巴细胞升高有关。

Mechanism of immune response in the gestational hypertension

To investigate the immune tolerance of pregnant patients with hypertension, 42 patients with gestational hypertension were enrolled as the observation group. 50 normal pregnant women at the same period were used as the control group. Compare the levels of leukocyte antigen and T lymphocytes in the two groups and analyze their effects on immune response. Results showed, compared with the control group, the diastolic blood pressure and urine protein in the observation group increased significantly, the expression of leukocyte antigen mRNA was significantly reduced, the serum leukocyte antigen concentration was significantly lower, and the levels of T-lymphocyte CD3⁺, CD4⁺ and CD8⁺ were significantly higher. The results suggest that the decreased immune tolerance in gestational hypertension patients is related to lower level of white blood cell antigen in patients with gestational hypertension, and the higher level of T lymphocytes.