| 放射工作人员外周血淋巴细胞核质桥水平及其影响因素分析 |
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| 引用本文： | 田雪蕾,陆雪,封江彬,吕玉民,田梅,刘青杰.放射工作人员外周血淋巴细胞核质桥水平及其影响因素分析[J].中华放射医学与防护杂志,2020,40(2):94-98. |
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| 作者姓名： | 田雪蕾 陆雪 封江彬 吕玉民 田梅 刘青杰 |
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| 作者单位： | 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088,中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088,中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088,河南省职业病防治研究院毒理研究室, 郑州 450052,中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088,中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088 |
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| 基金项目： | 国家自然科学基金（81573081） |
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| 摘 要： | 目的初步探讨放射工作人员的性别、年龄、工龄、工种和年有效剂量等因素对其外周血淋巴细胞核质桥(NPB)的影响。方法收集100例河南省放射工作人员外周血,利用细胞分裂阻滞实验(CBMN法)制备人外周血淋巴细胞NPB标本,分析NPB率和NPB细胞率及各类因素对NPB的影响。结果放射工作人员NPB率高于正常健康人群(Z=-8.123,P<0.01)。性别对NPB的影响差异无统计学意义(P>0.05),年龄、工龄、工种和年有效剂量均对NPB有影响(χ^2=7.202~45.571,P<0.05)。结论NPB能反映出长期小剂量慢性照射对职业受照人群健康的影响。
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| 关 键 词： | 核质桥 放射工作人员 影响因素 电离辐射 |
| 收稿时间： | 2019/4/9 0:00:00 |
Influence factors of nucleoplasmic bridge frequencies in the peripheral blood lymphocytes of radiation workers |
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| Tian Xuelei,Lu Xue,Feng Jiangbin,Lyu Yumin,Tian Mei and Liu Qingjie.Influence factors of nucleoplasmic bridge frequencies in the peripheral blood lymphocytes of radiation workers[J].Chinese Journal of Radiological Medicine and Protection,2020,40(2):94-98. |
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| Authors: | Tian Xuelei Lu Xue Feng Jiangbin Lyu Yumin Tian Mei and Liu Qingjie |
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| Institution: | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China,Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China,Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China,Laboratory of Toxicology, Henan Institution of Occupational Medicine, Zhengzhou 450052, China,Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China and Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China |
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| Abstract: | Objective To study the effects of sex,age,length of service,type of work and annual effective radiation dose on nucleoplasmic bridge(NPB)in the peripheral blood lymphocytes of radiation workers.Methods The peripheral blood samples of 100 radiation workers in Henan province were collected and the NPB in peripheral blood lymphocytes were measured by CBMN assay.The frequencies of NPB formation and NPB-containing cells were calculated,and the effects of various factors on NPB incidence were analyzed statistically.Results The NPB frequency in radiation workers was higher than that in healthy people(Z=-8.123,P<0.01).Except for sex,the factors of age,length of service,type of work and annual effective dose had significant influences on NPB(χ^2=7.202-45.571,P<0.05).Conclusions NPB reflects the effect of low-dose long-term chronic irradiation on the occupational radiation workers. |
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| Keywords: | Nucleoplasmic bridges Radiation worker Influence factors Ionizing radiation |
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