枸橼酸咖啡因治疗早产儿呼吸窘迫综合征的临床疗效及对神经发育的影响

探讨不同枸橼酸咖啡因治疗方案对早产儿呼吸窘迫综合征的临床疗效和神经发育的影响,分析本院收治的80例呼吸窘迫综合征早产儿临床资料,在采用枸橼酸咖啡因负荷量(每天,20 mg/kg)24 h后,分别使用维持量为每天10 mg/kg枸橼酸咖啡因(为观察组)或使用每天5mg/kg维持量 (为对照组)。结果显示,与治疗前相比,两组治疗后β-内啡肽(β-EP)显著降低,智力发展指数(MDI)、精神运动指数(PDI)显著提高。与对照组比较,且观察组β-EP降低幅度较大。结果说明,枸橼酸咖啡因每天10 mg/kg维持量比5mg/kg更有利于提高早产儿呼吸窘迫综合征的临床疗效,同时可改善神经发育。

Clinical efficacy of caffeine citrate in the treatment of respiratory distress syndrome in premature infants and its effect on neurodevelopment

To investigate the effects of different caffeine citrate treatment regiments on the clinical efficacy and neurodevelopment of premature infants with respiratory distress syndrome. The clinical data of 80 premature infants with respiratory distress syndrome admitted to our hospital were prospectively analyzed. After 24 hours, caffeine citrate load (20 mg/kg per day) was given, and the infants were treated with maintenance dose (10 mg/kg per day) as the observation group, caffeine citrate maintenance dose (5 mg/kg per day) as the control group. Results showed, compared to before treatment, beta-endorphin (beta-EP) in the two groups was significantly lower, the intelligence development index (MDI) and psychomotor index (PDI) of the two groups were significantly higher. In conclusion, the maintenance dose of caffeine citrate (10 mg/kg per day) is more beneficial to improve the clinical efficacy of respiratory distress syndrome in premature infants than that (5 mg/kg per day), and at the same time it can also improve neurological development.