| R语言计算药动学参数及生物等效性分析 |
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| 引用本文： | 吴正宇,方文韬,栾迪,丁言运,杨哲,赵亚男.R语言计算药动学参数及生物等效性分析[J].中国现代应用药学,2020,37(3):308-313. |
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| 作者姓名： | 吴正宇 方文韬 栾迪 丁言运 杨哲 赵亚男 |
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| 作者单位： | 皖南医学院 研究生学院,安徽医健领航医药科技有限公司,皖南医学院 研究生学院,皖南医学院 研究生学院,皖南医学院 研究生学院,安徽医健领航医药科技有限公司;皖南医学院第一附属医院弋矶山医院 |
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| 基金项目： | 皖南医学院弋矶山医院第二周期学术带头人 |
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| 摘 要： | 目的使用R语言计算非房室模型药动学参数,并进行生物等效性分析。方法使用R语言中"NonCompart"包进行非房室模型药动学参数的计算。使用"nlme"包建立线性混合效应模型,进行多因素方差分析。使用"PowerTOST"包计算90%置信区间。将结果与Phoenix WinNonlin 6.4软件的计算结果对比。结果联合使用R包进行非房室模型药动学参数的计算与生物等效性分析的结果与Phoenix WinNonlin 6.4软件计算结果一致。结论可以通过R语言实现非房室模型药动学参数的计算与生物等效性分析,且结果可靠。
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| 关 键 词： | R语言 药动学 生物等效性 |
| 收稿时间： | 2019/1/21 0:00:00 |
| 修稿时间： | 2019/6/19 0:00:00 |
Pharmacokinetic Parameters Calculation and Bioequivalence Analysis by R Software |
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| WU Zhengyu,FANG Wentao,LUAN Di,DING Yanyun,YANG Zhe and ZHAO Yanan.Pharmacokinetic Parameters Calculation and Bioequivalence Analysis by R Software[J].The Chinese Journal of Modern Applied Pharmacy,2020,37(3):308-313. |
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| Authors: | WU Zhengyu FANG Wentao LUAN Di DING Yanyun YANG Zhe and ZHAO Yanan |
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| Institution: | Graduate School, Wannan Medical College, Wuhu 241001, China,Anhui Yijian Leading Medical Techology Co., Ltd., Hefei 230031, China,Graduate School, Wannan Medical College, Wuhu 241001, China,Graduate School, Wannan Medical College, Wuhu 241001, China,Graduate School, Wannan Medical College, Wuhu 241001, China and Anhui Yijian Leading Medical Techology Co., Ltd., Hefei 230031, China;Yijishan Hospital of Wannan Medical College, Wuhu 241001, China |
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| Abstract: | OBJECTIVE To calculate the pharmacokinetic parameters of non-compartmental models and analysis bioequivalence by use R software. METHODS The pharmacokinetic parameters of the non-compartmental model were calculated by the "NonCompart" package in the R software. A linear mixed-effects model was built using the "nlme" package for multivariate analysis of variance. Use the "PowerTOST" package to calculate the 90% confidence interval of geometric mean ratio. The results was compared with the Phoenix WinNonlin 6.4 software. RESULTS The results of pharmacokinetic parameters of the non-compartmental model and bioequivalence analysis by using the R software were consistent with result which calculated by Phoenix WinNonlin 6.4 software. CONCLUSION The pharmacokinetic parameters of non-compartmental model calculation and bioequivalence analysis can be achieved by R software and the result is reliable. |
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| Keywords: | R software pharmacokinetic Bioequivalence |
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