Surface antigens on malignant Sezary and T-CLL cells correspond to those of mature T cells |
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Authors: | Boumsell, L Bernard, A Reinherz, EL Nadler, LM Ritz, J Coppin, H Richard, Y Dubertret, L Valensi, F Degos, L Lemerle, J Flandrin, G Dausset, J Schlossman, SF |
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Abstract: | Tumor cells from eight adult patients with T-cell chronic malignancies were investigated with a series of monoclonal antibodies recognizing T- cell differentiation antigens. This series allowed definition of discrete subpopulations of mature T cells with functional specialization. All six patients with Sezary syndrome and one patient with T-chronic lymphocytic leukemia had cells with the same phenotype as normal helper/inducer T cells, whereas the other patient with T- chronic lymphocytic leukemia had cell with the same phenotype as normal cytotoxic/suppressor T cells. Some clinical manifestations observed in these patients may reflect retention of functional activities by their malignant cells. |
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