Caspase-3和Caspase-8在婴幼儿血管瘤中的表达和意义

目的：探讨半胱氨酸天冬氨酸蛋白酶-3（Caspase-3）和半胱氨酸天冬氨酸蛋白酶-8（Caspase-8）在各阶段婴幼儿血管瘤组织中的表达及其与婴幼儿血管瘤消退的关系。方法：采用Westernblot和RT-PCR方法检测Caspase-3和Caspase-8及mRNA在15例不同时期婴幼儿血管瘤组织中的表达。结果：Caspase-3和Caspase-8在各期均有表达，在增生早期和中期表达较弱，增生晚期表达最强，消退期表达减少，但仍有表达；Caspase-3mRNA和Caspase-8mRNA在各期均有表达，增生晚期表达显著，消退期表达减少。结论：Caspase-3和Caspase-8参与了婴幼儿血管瘤细胞的凋亡过程，它们的活化诱导了细胞凋亡的发生，可能在婴幼儿血管瘤自发消退的过程中发挥着作用。

The expresstion and role of Caspase-3 and Caspase-8 in infantile hemangioma

Objective To study the relationship between expression of Caspase-3 and Caspase-8 and regression of infantile hemangioma. Methods The expression of Caspase-3 and Caspase-8 and mRNA was detected in different stages of 15 infantile hemangiomas by Western blot and RT-PCR. Results Caspase-3 and Caspase-8 were detected in all the stages.In the early and middle proliferating stage,the expression of Caspase-3 and Caspase-8 was weak and strongest in the late proliferating stage.In the regressing stage,the expressio...