Relationships between sex hormone levels in men over 50 years of age and body composition, bone quality, and quality of life |
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| Authors: | Martínez-Jabaloyas J M Queipo-Zaragozá A Ferrandis-Cortes C Queipo-Zaragozá J A Gil-Salom M Chuan-Nuez P |
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| Affiliation: | 1. Servicio de Urología, Hospital Clínico Universitario de Valencia, Valencia, España;2. Laboratorio de Bioquímica Clínica, Hospital Clínico Universitario de Valencia, Valencia, España;3. Servicio Urología, Hospital Clínico de Sagunto, Valencia, España;1. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, USA;2. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;3. Department of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA;4. Department of Global Health, University of Washington, Seattle, WA 98104, USA;1. Partners MS Center, Brigham and Women''s Hospital (BWH), Harvard Medical School, Brookline, Boston, MA United States;1. Unidad de Arritmias, Servicio de Cardiología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España;2. Departamento de Endocrinología y Nutrición, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España;3. Departamento de Medicina Clínica, Universidad Miguel Hernández, Elche, Alicante, España;1. Servicio de Medicina Interna, Hospital Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, España;2. Servicio de Microbiología y Parasitología, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca, CSIC, Salamanca, España;3. Departamento de Ciencias Biomédicas y del Diagnóstico, Universidad de Salamanca, Salamanca, España;4. Servicio de Medicina Interna, Sección de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Universidad de Salamanca, Salamanca, España;1. Fellow Pediatrician, Pediatric Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal;2. MD. Pediatric Intensive Care Unit, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal;3. MD. Chief, Pediatric Intensive Care Unit of Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal |
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| Abstract: | ![]()
ObjetiveTo determine whether there was a relationship between sex hormone levels and body composition, bone health, and health-related quality of life in men over 50 years of age.Material and methodsTransversal study carried out in 230 Spanish male outpatients. Body composition was studied using direct anthropometric measures: height, weight, waistline circumference, dominant arm circumference, tricipital skinfold, dominant arm skinfold, subscapular skinfold. Calculated anthropometric parameters were obtained. Quantitative ultrasound measurements of the calcaneus were performed and bone turnover markers were determined (N-telopeptides urinary excretion and calcium/creatinine urinary rate). Quality of life was studied using the short form 36 questionnaire (SF-36). Blood tests included total testosterone, sex hormone binding-globulin, calculated free testosterone (cFT), dehydroepiandrosterone sulphate (DHEA-S), androstenedione, 17-β-estradiol and gonadotrophins.ResultscFT was associated with increased muscle and to decreased in fat content, even after adjusting for age (p < 0.05). Bone density was only related to estradiol and its bioavailable fraction (p < 0.05). DHEA-S and cFT were related (p < 0.05) to some SF-36 subscales.ConclusionscFT level is most associated with body changes that accompany aging. Androgen levels are not related to bone density. Decline in cFT and DHEA-s levels might be related to decreased quality of life. |
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