Role of myeloid human cytomegalovirus infection in children's idiopathic thrombocytopenic purpura |
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| Authors: | Ding Yan Zhao Lei Mei Hong Zhang Shu-Ling Huang Zhi-Hua |
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| Affiliation: | a Department of Gastroenterology and Hepatology, Wuhan Children's Hospital, Wuhan, Hubei Province, People's Republic of Chinab Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People's Republic of Chinac Department of Hepatology and Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People's Republic of China |
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| Abstract: | This project explores the specificity of myeloid human cytomegalovirus (HCMV) infection in pathogenesis of idiopathic thrombocytopenic purpura (ITP). Eighty-one subjects with ITP were observed. HCMV early antigen and related myeloid cells in bone marrow, and platelet, HCMV IgM, and IgG in blood were tested. The results presented potent evidence that myeloid HCMV infection is a specific factor in children's ITP: patients of ITP with myeloid HCMV infection had a tendency for exacerbation, refractoriness, and chronic advance. However, HCMV did not affect the quantity of megakaryocyte, which showed the complicated relationships between HCMV and ITP. |
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| Keywords: | blood platelet bone marrow human cytomegalovirus idiopathic thrombocytopenic purpura |
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