依达拉奉联合丹参注射液治疗急性脑梗死的疗效观察

目的观察依达拉奉联合丹参注射液治疗急性脑梗死的临床疗效。方法选取2013-05-2015-03我院收治的急性脑梗死患者88例为研究对象,按照随机数字表法分为观察组和对照组各44例,其中对照组在神经内科常规治疗基础上加用丹参注射液,观察组在对照组基础上加用依达拉奉治疗。观察比较2组治疗前、后的神经功能缺损情况、肢体运动功能情况、日常生活能力评分及不良反应。结果组间比较,对照组治疗前神经功能缺损程度评分、Barthel指数评分和Fugl-Meyer评分与观察组差异无统计学意义(P0.05);观察组治疗后的神经功能缺损程度评分、Barthel指数评分和Fugl-Meyer评分改善情况明显优于对照组,差异具有统计学意义(P0.05)。组内比较,2组治疗后神经功能缺损程度评分、Barthel指数评分和Fugl-Meyer评分较治疗前均有明显改善,差异具有统计学意义(P0.05)。2组治疗期间均未出现严重不良反应。结论急性脑梗死应用依达拉奉联合丹参注射液治疗,能及时有效地清除自由基,保护脑组织,显著改善患者生活能力、神经功能和运动能力,提高患者生活质量,因此值得临床工作红推广应用。

Observation of curative effect of edaravone combined with Danshen injection in the treatment of acute cerebral infarction

Objective To observe the clinical curative effects of edaravone combined with Danshen injection for acute cerebral in-farction(ACI).Methods We selected 88 cases with acute cerebral infarction from May 2013 to May 2015 as study objects,and di-vided them into observation group and control group on the basis of the random number table method,44 cases in each group.In addition to routine therapy in neurology department,Danshen injection was applied to control group and the combined treatment of edaravone and Danshen injection was used to observation group.The neurological deficits,limb movement,activity of daily living and adverse events before and after treatment were recorded.Results Before treatment,there were no differences between two groups in terms of NIHSS scores,Barthel index scores and Fugl-Meyer scores(P>0.05),after treatment all of which were obvi-ously ameliorated in both two groups(P<0.05)and were better improved in the observation group compared with control group (P<0.05).The two groups showed no severe adverse reactions during the treatment period.Conclusion The combination of edaravone and Danshen injection which can effectively clean free radical,protect brain tissues,improve the activity of daily living, neurological function and movement ability and elevate the quality of life,should be worthy of popular application.