头颈部肿瘤蜘~(99)Tc-MIBI阳性显像的临床研究

目的探讨~(99m)Tc-MIBI亲肿瘤显像在头颈部肿瘤定性诊断中的应用价值。方法 91例临床初诊为头颈部肿瘤的患者和20例正常志愿者进行了早期和延迟的~(99m)Tc-MIBI头颈部断层显像。结果 ~(99m)Tc-MIBI早期／延迟显像诊断头颈部恶性肿瘤的总体灵敏度、特异性、准确性及阳性预测值分别为78.7％／72.3％、72.1％／ 88.4％、75.6％／80.0％和75.5％／87.2％；鼻咽癌、非霍奇金淋巴瘤显像效果优于上颌窦癌。~(99m)Tc-MIBI显像对于鼻咽癌复发／残留以及鼻腔非霍奇金淋巴瘤定性诊断价值明显优于CT和MRI检查。结论 ~(99m)Tc-MIBI亲肿瘤显像在头颈部肿瘤的定性诊断中有较好的应用前景,在判断肿瘤的范围、局部侵犯及发现颅底、颅内的转移灶等方面有独特的优势。

Clinical Investigation of ~(99m)Tc-MIBI Imaging in Head and Neck Tumors

To investigate the diagnostic potential value of ~(99m)Tc-MIBI imaging in head and neck tumors. Methods: Ninety-one patients with malignant and benign head and neck lesions were subjected to ~(99m)Tc-MIBI tomography, and 20 healthy volunteers served as control group. Results: The overall sensitivity, specificity, accuracy and positive predictive accuracy of early/delay ~(99m)Tc-MIBI imaging in diagnosis of head and neck malignant tumors were 78.7%/72.3%, 72.1%/88.4%, 75.6%/80.0% and 75.5%/87.2% respectively. The results of ~(99m)Tc-MIBI Imaging in diagnosis of nasopharyngeal cancer and sinonasal non-Hodgkin's lymphoma were more satisfactory than those in maxillary sinus cancer. In distinguishing recurrent/residual nasopharyngeal carcinoma and sinonasal non-Hodgkin's lymphoma, ~(99m)Tc-MIBI scintigraphy was superior to CT/MRI. Conclusion: ~(99m)Tc-MIBI imaging is a promising useful tool in identifying head and neck tumor, and it has a special value to evaluate the local invasion and metastasis involved.