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Plasma cell leukemia with lobulated nuclei: One case report
Authors:Kunio Yano  Masahide Kobayashi  Kazunari Iijima  Kazunori Kawane  Sumiko Hamanaka
Affiliation:(1) Department of Infectious Diseases, Hamamatsu Medical Center, 328 Tomitsuka, 432 Hamamatsu, Japan;(2) Department of Hematology, Hamamatsu Medical Center, Hamamatsu, Japan;(3) Department of Pathology, Hamamatsu Medical Center, Hamamatsu, Japan;(4) Department of Hematology, Seirei-Mikatabara Hospital, Hamamatsu, Japan
Abstract:
The case of an 80-year-old man with plasma cell leukemia characterized by basophilic cytoplasm, and extensive lobulated nuclei is described. In spite of the peculiar morphologic nuclei, the diagnosis was based on the presence of M protein and Bence Jones protein in the serum and urine, immunophenotypic characteristics, immunoglobulin gene rearrangement, and findings of transmission electron microscopy.
Keywords:plasma cell leukemia  lobulated nuclei  electron microscopy
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