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联合检测血清CA153、CEA在乳腺癌中的表达及临床意义
引用本文:刘晓玲,李明众,王雯,姜缨. 联合检测血清CA153、CEA在乳腺癌中的表达及临床意义[J]. 实用放射学杂志, 2006, 22(8): 993-994
作者姓名:刘晓玲  李明众  王雯  姜缨
作者单位:西安交通大学第一医院放疗科,陕西,西安,710061
摘    要:目的探讨乳腺癌患者血清糖类抗原153(CA153)和癌胚抗原(CEA)表达及临床意义。方法利用全自动快速粒子酶免疫分析系统(IMX),检测30例健康人、52例乳腺良性疾病和208例乳腺癌患者血清CA153和CEA的水平,分析CA153和CEA检测值与乳腺癌临床特征之间的关系。结果乳腺癌患者治疗前血清CA153及CEA的水平明显高于治疗后的水平(P<0.001),初诊初治及复发转移患者的血清CA153及CEA的水平明显高于乳腺良性病变和健康人群(P<0.001);联合检测可以提高对乳腺癌诊断的阳性率。结论联合检测CA153及CEA水平可以提高对乳腺癌诊断的敏感性和准确性,并可用于该肿瘤的预后判断。

关 键 词:乳腺  乳腺癌  糖类抗原153  癌胚抗原
文章编号:1002-1671(2006)08-0993-03
修稿时间:2006-04-12

Study on Expression of CA153, CEA and Its Clinical Significance in the Patients with Breast Cancer
LIU Xiao-ling,LI Ming-zhong,WANG Wen,JIANG Ying. Study on Expression of CA153, CEA and Its Clinical Significance in the Patients with Breast Cancer[J]. Journal of Practical Radiology, 2006, 22(8): 993-994
Authors:LIU Xiao-ling  LI Ming-zhong  WANG Wen  JIANG Ying
Abstract:Objective To investigate the expression of carbohrdyate antigen (CA153 ) and carcinoembryanic antigen(CEA) ,and itsclinical significance in the patients with breast cancer.Methods The sera CA153,CEA levels were determined by IMX in 30 healthypersons,52 patients with benign breast diseases and 208 patients with breast cancer from 1998 to 2002 ,the correlation between the CA153,CEA level and the clinical characteristics was also detected.Results In the patients with breast cancer, the level of serum CA153 and CEA was significant higher in pre-treatment than that in post-treatment(P<0.001), and these both level of CA153 and CEA was also higherin the patients who were first visitors and had metastasis than that in the patients with benign breast diseases and healthy persons(P<0.001),the positive rate in diagnosis breast cancer could be raised by combined test of serum CA153 and CEA. Conclusion The combination test of serum CA153 and CEA level can improve the diagnostic rate of breast cancer and can be used for prediction of prognosis.
Keywords:breast  breast cancer  carbohrdyate antigen 153(CA153)  carcinoembryanic antigen(CEA)
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