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| 趋化因子受体CCR5的研究进展 | |
| 引用本文： | 朱长斌,蒋子恺,程枫,钱关祥. 趋化因子受体CCR5的研究进展[J]. 上海交通大学学报(医学版), 2012, 32(6): 809-814 |
| 作者姓名： | 朱长斌 蒋子恺 程枫 钱关祥 |
| 作者单位： | 1. 上海交通大学医学院临床医学系,上海,200025 2. 上海交通大学基础医学院教学实验中心,上海,200025 3. 上海交通大学基础医学院生物化学与细胞分子生物学系,上海,200025 |
| 基金项目： | 上海市大学生创新性实验计划 |
| 摘 要： | CCR5为趋化因子CC受体家族成员,属7次跨膜G蛋白耦联受体,配体为CCL3 (MIP-1α)、CCL4( MIP-1β)、CCL5( RANTES).CCR5主要表达于单核/巨噬细胞和淋巴细胞,与其配体介导CCR5+免疫细胞的趋化、募集过程.因此,多种免疫性疾病的发生和发展过程均有CCR5参与.CCR5是人类免疫缺陷病毒Ⅰ型(HIV-1)入侵时的重要辅助受体,而在肿瘤细胞和各类肿瘤相关间质细胞的表面也可见其表达,并介导肿瘤增殖、浸润等多种生物学过程.随着相关研究技术的发展,进一步加深了对CCR5的结构、功能、信号通路及其在相关疾病中的作用的认识. |
| 关 键 词： | 趋化因子受体 CCR5 免疫性疾病 肿瘤 |
Research progress of chemokine receptor CCR5 |
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| ZHU Chang-bin , JIANG Zi-kai , CHENG Feng , QIAN Guan-xiang. Research progress of chemokine receptor CCR5[J]. Journal of Shanghai Jiaotong University:Medical Science, 2012, 32(6): 809-814 | |
| Authors: | ZHU Chang-bin JIANG Zi-kai CHENG Feng QIAN Guan-xiang |
| Affiliation: | 1.School of Clinical Medicine,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;2.Experiment Teaching Center,Basic Medical College,Shanghai Jiaotong University,Shanghai 200025,China;3.Department of Biochemistry and Molecular Biology,Basic Medical College,Shanghai Jiaotong University,Shanghai 200025,China) |
| Abstract: | CCR5,as the member of CC receptor family,with its ligands being CCL3(MIP-1α),CCL4(MIP-1β) and CCL5(RANTES),is categorized as 7 trans-membrane domain G-protein coupled receptor.CCR5 is expressed in monocytes/macrophages as well as lymphocytes inducing chemotaxis and recruitment in inflammatory response and is an important co-receptor of human immunodeficiency virus(HIV)-1 virus,leading to the multifunction of CCR5 in progression of various kind of immunological diseases and invasion of HIV-1.Moreover,the expression of CCR5 on the surface of tumor cells and stromal cells contributes to mediating multiple biological behaviors of cancers such as proliferation and invasion.Advanced technologies also lead to the revealing of structure,function,signal transduction and roles of CCR5 in the progression of related diseases. |
| Keywords: | chemokine receptor CCR5 immunological disease cancer |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |