重组人生长激素和全肠外营养支持对腹腔感染患者低白蛋白血症的治疗作用

目的观察全肠外营养支持（ＴＰＮ）和重组人生长激素（ｒｈＧＨ）对严重腹腔感染患者低白蛋白血症的治疗作用。方法１７例腹腔感染患者分为对照组（８例）和肌肉注射ｒｈＧＨ组（ＧＨ组，９例），两组患者的治疗和ＴＰＮ方案相同，ＧＨ组患者另外连续肌注ｒｈＧＨ７天（１２Ｕ／ｄ）。观察患者体重、血浆蛋白浓度的变化。结果ＧＨ组患者，治疗后血清白蛋白、前白蛋白、转铁蛋白浓度均显著高于治疗前（Ｐ＜００１），对照组患者治疗前后差异无显著意义（Ｐ＞００５）。结论腹腔感染时单纯ＴＰＮ支持并不能显著促进血浆蛋白的合成，而在ＴＰＮ的基础上加ｒｈＧＨ，能显著提高腹腔感染患者的血浆蛋白水平

Effect of recombinant human growth hormone with total parenteral nutrition on albumin synthesis in patients with peritoneal sepsis

Objective To investigate the effect of recombinant human growth hormone (rhGH) in combination with total parenteral nutrition (TPN) on albumin synthesis in patients with peritoneal sepsis. Method 17 patients with peritoneal sepsis were divided randomly into two groups.The control group received TPN only for 7 days, and the GH group received both rhGH (12 U/d) and TPN for 7 days. The TPN scheme and other treatment were the same in the two groups. Result Serum albumin,prealbumin,and transferrin concentration were increased in patients in the GH group( P <0 01),but no apparent effect was observed in the control group( P >0 05). Conclusion In condition of serious peritoneal sepsis,TPN can not increase albumin,prealbumin,and transferrin synthesis alone,whereas rhGH in combination with TPN significantly increase the synthesis of visceral proteins.