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| 放射免疫法研究乳糖基重组人生长激素和重组人生长激素的药代动力学 | |
| 引用本文： | 陈泽莲,李铜玲,庞其捷,何菊英,彭永富,李云春,管昌田. 放射免疫法研究乳糖基重组人生长激素和重组人生长激素的药代动力学[J]. 中国药房, 2002, 13(10): 583-584 |
| 作者姓名： | 陈泽莲 李铜玲 庞其捷 何菊英 彭永富 李云春 管昌田 |
| 作者单位： | 1. 四川大学华西医院药剂科,成都市,610041 2. 四川大学药学院,成都市,610041 3. 第三军医大学西南医院药剂科,重庆市,400038 4. 四川大学华西医院核医学科成都市,610041 |
| 基金项目： | 国家自然科学基金资助项目 (39670861) |
| 摘 要： | 目的 :比较研究乳糖基重组人生长激素 (L -rhGH )和重组人生长激素 (rhGH )在小鼠血和肝中的药代动力学。方法 :用注射免疫法测定L -rhGH和rhGH在小鼠血、肝脏中的药物浓度。结果 :静脉注射后 ,两者的药代动力学过程存在显著性差异 ,L -rhGH在肝中的分布量较rhGH增加 ,且T1/2 仅为rhGH的17 9 % ;L -rhGH在血中亦表现为短维持时间、低分布量。结论 :L -rhGH呈现出更符合人体生理的药代动力学特征 |
| 关 键 词： | 乳糖基重组人生长激素 重组人生长激素 药代动力学 放射免疫法 |
| 文章编号： | 1001-0408(2002)10-0583-02 |
| 修稿时间： | 2002-01-15 |
Pharmacokinetic Analysis for Lactosaminated Recombination Human Growth Hormone and Recombination Human Growth Hormone by Radioimmunoassay |
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| CHEN Zelian. Pharmacokinetic Analysis for Lactosaminated Recombination Human Growth Hormone and Recombination Human Growth Hormone by Radioimmunoassay[J]. China Pharmacy, 2002, 13(10): 583-584 | |
| Authors: | CHEN Zelian |
| Abstract: | OBJECTIVE:To study the pharmacokinetics of L-rhGH and rhGH in mice.METHODS:The concertrations of L-rhGH and rhGH in plasma and liver were measured by radioimmunoassay.RESULTS:After intravenous injection,there were significant differences between L-rhGH and rhGH in pharmacokinetic parameters.The Cmax of L-rhGH in the liver was higher than that of rhGH but the T1/2 of L-rhGH was only 17.9% of T1/2 of rhGH;the Cmax of L-rhGH in plasma was lower than that of rhGH and the T1/2 was shorter.CONCLUSION:L-rhGH reveals the pharmacokinetic characteristics which fits in with the physiology of human body. |
| Keywords: | lactosaminated recombination human growth hormone recombination human growth hormone pharmacokinetics radioimmunoassay |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |