| Abstract: | ![]()
Single unit discharges in the ventromedial hypothalamic nucleus (VMH) and lateral hypothalamic area (LH) were recorded extracellularly in anesthetized cats, while amino acid solutions were perfused through the small intestine via implanted cannulae. Test infusions consisted of 5 amino acid mixtures (arginine, leucine, phenylalanine, tryptophan, alanine: 50 mM each), 5.0% casein hydrolysate; arginine 125 mM (2.2%); leucine 125 mM (1.6%). Sixty-six units were recorded in 30 cats. Of 52 tested in the LH, 19 or 37% were affected: 14 increased and 5 decreased in firing rate in response to amino acid intestinal perfusions with a very short latency consistent with activation of intestinal amino acid receptors. Of 14 neurons tested in VMH, only 3 or 21% were activated by amino acid infusions but with a long latency of several minutes which cannot exclude the involvement of a postabsorptive signal. Results are discussed in terms of intestinal afferent control over hypothalamic neuronal activity related to amino acid induced satiety. |
