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恶性黑素瘤和良性黑素细胞肿瘤bcl-2蛋白表达
引用本文:张士发 路平. 恶性黑素瘤和良性黑素细胞肿瘤bcl-2蛋白表达[J]. 中国皮肤性病学杂志, 1999, 13(3): 133-134
作者姓名:张士发 路平
作者单位:[1]沈阳军区总医院皮肤科 [2]中国医科大学附一院
摘    要:
目的探讨bcl 2蛋白在恶性黑素瘤(MM)中的表达及其意义。方法应用免疫组化方法对24例MM的bcl 2蛋白表达进行了检测。结果15/24的MM的瘤细胞阳性,且bcl 2蛋白表达强度与MM的病理分级呈低度正相关(rs′=0.471,P<0.05),而良性黑素细胞肿瘤则极少表达bcl 2蛋白。结论bcl 2蛋白与MM的发展有关。

关 键 词:黑色素瘤  bcl-2蛋白

Expression of bcl 2 Protein in Malignant Melanoma and Benign Melanocyte Cell Tumors.
Zhang Shifa,Luping,Yue Hui,et al.. Expression of bcl 2 Protein in Malignant Melanoma and Benign Melanocyte Cell Tumors.[J]. The Chinese Journal of Dermatovenereology, 1999, 13(3): 133-134
Authors:Zhang Shifa  Luping  Yue Hui  et al.
Affiliation:Zhang Shifa,Luping,Yue Hui,et al.Department of Dermatology,General Hospital of Shenyang Military Region,Shenyang 110015
Abstract:
Objective To study the expression of bcl 2 protein in malignant melanoma (MM) and its significance.Method The expression of bcl 2 protein in 24 cases of MM was detected by immunohistochemical method.Results 15/24 cases were bcl 2 protein positive on tumor cells in MM and the expressive intensity of bcl 2 protein was low degree correlated to the pathologic degree of MM(r s′=0.471,P<0.05),but bcl 2 protein was less expressed in benign melanocytic cell tumors.Conclusion bcl 2 proein is correlated with the progression of MM.
Keywords:Melanoma bcl 2 protein  
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