Aqueous amino acid levels in Fuchs' corneal dystrophy |
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| Authors: | W N Rosenthal M Blitzer M S Insler |
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| Affiliation: | 1. Department of Ophthalmology, Tulane University School of Medicine, New Orleans;2. Department of Genetics, Tulane University School of Medicine, New Orleans;1. Department of Ophthalmology III, CHNO des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France;2. Institut de La Vision, Sorbonne Université, Inserm, CNRS, IHU FOReSIGHT, 17, rue Moreau, 75012 Paris, France;3. Department of Ophthalmology, Ambroise Paré Hospital, AP–HP, University of Versailles Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France;1. School of Civil Engineering, Sichuan University of Science and Engineering, Zigong 643000, China;2. School of Environment, Harbin Institute of Technology, Harbin 150001, China;3. Students of Affairs Division, Sichuan University of Science and Engineering, Zigong 643000, China;4. School of Life Science and Engineering, Southwest Jiaotong University, Cheng Du 610031, China;1. Bateson Centre and Department of Biomedical Science, University of Sheffield, Western Bank Sheffield, S10 2TN, UK;2. Wellcome Trust Brenner Building, Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Beckett Street, Leeds LS9 7TF, UK;1. School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, PR China;2. Liaoning Engineering Technology Research Centre of Function Fiber and its Composites, Dalian 116034, PR China;1. College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety, Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, No. 3 Wenyuan Road, Nanjing, Jiangsu 210023, China;2. Nanjing Institute for Food and Drug Control, Nanjing, Jiangsu 210038, China;3. College of Life Science, Anhui Normal University, Wuhu, Anhui 241000, China |
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| Abstract: | ![]()
Eight patients with Fuchs' corneal dystrophy and 11 matched senile cataract patients were examined at the time of surgery for aqueous humor amino acid levels. The cataract patients had amino acid levels that did not differ significantly from control values. The anterior chamber concentrations of threonine, glutamine, and arginine were found to be significantly increased in the patients with Fuchs' corneal dystrophy. Asparagine, phosphoserine, and phosphoethanolamine were found to be significantly decreased in patients with Fuchs' dystrophy. |
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