男性糖耐量低减的骨密度分析

为探讨男性糖耐量低减者(IGT)患者骨密度(BMD)改变趋势及其相关机制。测定69例IGT患者(IGT—1组:n=32,餐后2小时血糖>7.8mmol/L、<9.4mmol/L;IGT—2组:n=37,餐后2小时血糖≥9.4mmol/L、<11.1mmol/L)及60例年龄相匹配的健康对照者股骨近端(Neck,Troch,ward三角)、正位腰椎(L(2～4))BMD、血钙(ca)、磷(P)、24小时尿钙(U—Ca)、尿磷(U—P)、晨尿ca/cr。结果对照组与IGT—1组、IGT—2组的血钙、磷、24小时尿钙、磷、Neck、Troch、ward、L(2～4)4个部位的BMD比较差异无显著(P>0.05)。IGT—1组与对照组尿Ca/Cr比较差异无显著意义(P>0.05),IGT—2组与对照组尿Ca/Cr比较明显高于对照组(P<0.05)。IGT—1组、IGT—2组与对照组BMD比较:Neck分别下降0.2%、2.8%;Troch分别下降0.5%、4.44%;Ward分别为:增加0.3%、下降1.5%;L(2～4)分别下降0.22%、0.2%;尿钙排出增加6.8%、13.8%。结果示IGT患者的Neck、Troch的BMD呈下降趋势。IGT患者骨量改变特点为:血糖升高,尿钙排出增加,骨吸收增加。

Analysis of the Bone Density of Male Patients with Impaired Glucose Tolerance

To study changing tendency and relative mechanism of bone density (BMD) of male patients with impaired glucose to leronce (IGT). The bone density of femur (Neck,Troch, Ward)and upright lumbar (L2-4)'blood - calcium,blood - phosphorus,urine - cal -cium(U -Ca) ,urine - phosphorus (U - P) in 24 hours and Ca/Cr in early morning were measured in control group(60 normal persons) and IGT group (69 cases)(IGT-1 group: n =32,7. 8mmol/L<2h postpra - ndial blood -glucose<9. 4mmol/L;IGT -2 group: n =37,9. 4mmol/L≤2h postprandial blood - glucose< 11. Immol/L). Results The blood - calcium,blood - phosphorus, 24h U -Ca,24h U - P and bone density of femur(Neck ,Trock,Ward and L2-4in control group were not statisti-cally different from those in IGT-1 group and IGT -2 group( P >0. 05). The urine Ca/Cr in IGT -1 group and those in control group showed no obvious difference( P >0. 05). Urine Ca/Cr in IGT-2 group showed obviously higher than those in control group( P <0. 05). Compared bone density of IGT-1 group,IGT -2 group with those of control group:Neck reduced 0. 2% and 2. 8%,Troch reduced 0. 5% and 4. 44%,Word increased 0. 3% and reduced 1. 5% ,L2-4reduced 0. 22% and 0. 2% ,U -Ca increased 6. 8% and 13. 8. The results implied that BMD in Neck and Troch of IGT patients show reduc - ed tendency. The character of IGT patients' bone mass is that high blood - glucose,both U - Ca and bone absorption increases.