乌拉地尔预防气管插管时心血管反应的观察

为观察乌拉地尔预防气管插管时心血管的反应,将56例(ASA Ⅰ～Ⅱ)全麻择期手术患者分为A(n=28),B(n=28)两组。麻醉用安定0.2mg.kg~(-1),氟芬合剂1/2～1/4剂,2.5%硫喷妥钠4～7mg.kg~(1),琥珀胆碱1.5～2mg.kg~(-1)后B组直接气管插管;A组静注硫喷妥钠后即静注乌拉地尔0.5mg.kg~(-1),再静注琥珀胆碱后插管。结果:A组插管后心血管反应较稳定。收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心率(HR)和心率—收缩压乘积(RPP)明显升高,但升高的幅度较小(P<0.05);B组插管后上述参数显著升高(P<0.01),而且比A组高得多,组间比较有显著差异(P<0.05)。结果提示乌拉地尔能有效地预防气管插管引起的心血管反应。

Effects of Urapidial on Cardiovascular Responses to Tracheal Intubation

To observe the effects of urapidal on the cardiovascular responses to tracheal intubation, fifty -six patients (ASA I - I ) werw randomly divideded into group A( n - 28) and group B( n =28) .Anesthesia was induced with valium 0. 2mg. kg,2. 5% thiopental sodium 4-7mg. kg,and tracheal intubation was facilitated with succinylcholine. urapidil 0. 5mg. kg was intravenouslly given after administration of succinylcholine in group A. after intubation,changrs of SBP.DBP,MAP,HR.RPP were observed in both groups Imin,3mnu5min,7min after intubation result: It showed that in urapidial group all cardiovascular paramters were significantly lower ( P <0. 05) , Imin after Intubation. SBP and RPP were significantly lower(P <0. 05) , 3min after intubation, ccn-clusion: urapidil mright ameliorate the cardiovascular response to intubation.