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Elevated leukocyte count in asymptomatic subjects is associated with a higher risk for cerebral white matter lesions |
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| Authors: | Kim Chi Kyung Lee Seung-Hoon Kim Beom Joon Ryu Wi-Sun Choi Seung Ho Oh Byung-Hee Yoon Byung-Woo |
| Affiliation: | a Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea b Clinical Research Center for Stroke, Seoul National University Hospital, Seoul, Republic of Korea c Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea |
| Abstract: | ObjectiveCerebral white matter lesions (WMLs) are radiologic markers of small vessel disease in brain, and inflammatory processes were related to WMLs. We propose to determine if elevated leukocyte count was associated with a higher risk of WMLs.Methods1586 asymptomatic subjects who visited our hospital for a routine health check-up were enrolled. Leukocyte counts were measured and the presence of moderate to severe WMLs was determined by brain MRI.ResultsThirty (1.9%) had moderate to severe WMLs, and a significant greater proportion (4.1%) of subjects in the highest leukocyte count quartile had moderate to severe WMLs. After adjusting by C-reactive protein, aspirin use and cardiovascular risk factors, the highest quartile of leukocyte count (≥6.7 × 109/L) was significantly associated with moderate to severe WMLs compared with the lowest quartile [adjusted odds ratio, 4.03; 95% confidence interval, 1.05-15.5].ConclusionThe authors report for the first time that an elevated leukocyte count is independently associated with moderate to severe WMLs. |
| Keywords: | Leukocyte count White blood cell White matter lesions Cerebral ischemia Inflammation |
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