|
|||||
|
|
| 丝裂原活化蛋白激酶信号转导通路与子宫内膜癌 | |
| 引用本文： | 黄珊珊（综述）,乔玉环,郭瑞霞（审校）. 丝裂原活化蛋白激酶信号转导通路与子宫内膜癌[J]. 国外医学:妇产科学分册, 2009, 36(1): 56-59 |
| 作者姓名： | 黄珊珊（综述） 乔玉环 郭瑞霞（审校） |
| 作者单位： | 郑州大学第一附属医院妇产科; |
| 摘 要： | 丝裂原活化蛋白激酶（MAPK）通路目前已鉴定出4条[细胞外信号调节激酶（ERK）1，2、P38丝裂原活化蛋白激酶（P38）、c-Jun氨基末端激酶（JNK）和ERK5]，其中ERK1／2通路可被多种刺激活化，通过调控细胞周期，抑制细胞凋亡。促进细胞增殖、迁移和侵袭等而与肿瘤的发生发展密切相关。许多子宫内膜癌相关因素通过MAPK／ERK通路起作用。雌激素可以通过非基因组转录效应迅速激活MAPK通路促进子宫内膜的的发生发展。综述MAPK／ERK信号通路的研究进展，重点论述MAPK／ERK信号通路与子宫内膜癌的关系及分子机制，以及MAPK／ERK通路抑制剂在肿瘤防治方面的临床应用前景。 |
| 关 键 词： | 丝裂原活化蛋白激酶 信号转导通路 雌激素 非基因组效应 子宫内膜癌 |
The Correlation Between MAPK Signal Transduction and Endometrial Cancer |
|
| HUANG Shan-shan,QIAO Yu-huan,GUO Rui-xia. The Correlation Between MAPK Signal Transduction and Endometrial Cancer[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 36(1): 56-59 | |
| Authors: | HUANG Shan-shan QIAO Yu-huan GUO Rui-xia |
| Affiliation: | HUANG Shan-shan,QIAO Yu-huan,GUO Rui-xia.The Frist Affiliated Hospital,Zheng Zhou University,Zhengzhou 450052,China |
| Abstract: | Four different mediators of the mitogen-activated protein kinase(MAPK)signaling pathway have been identified [extracellular signal-regulated kinase(ERK1/2),P38 mitogen-activated protein kinase(P38),c-Jun N-terminal kinase(JNK)and ERK5 ].The ERK1/2 pathway is closely linked to the initiation and development of tumors as a result of its activities in inhibiting apoptosis and promoting cell proliferation,migration and invasion.ERK1/2(and subsequently MAPK/ERK signaling)can be activated by any of a variety of s... |
| Keywords: | Mitogen-activated protein kinase Signaling pathway Estrogen Non-genomic effects Endometrial cancer |
| 本文献已被 CNKI 维普 等数据库收录！ | |