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| 不同缺氧时间对小鼠即时热板法痛阈和甩尾潜伏期的影响 | |
| 引用本文： | 王稳,魏晶晶,吴廷廷,王小娟,谢云,赵佳佳,黄辉,马高磊,张励才. 不同缺氧时间对小鼠即时热板法痛阈和甩尾潜伏期的影响[J]. 中国疼痛医学杂志, 2011, 17(7). DOI: 10.3969/j.issn.1006-9852.2011.07.012 |
| 作者姓名： | 王稳 魏晶晶 吴廷廷 王小娟 谢云 赵佳佳 黄辉 马高磊 张励才 |
| 作者单位： | 1. 徐州医学院麻醉学院 2. 徐州医学院公共卫生学院 3. 徐州医学院医学影像学院 4. 徐州医学院麻醉学院;江苏省麻醉学重点实验室,江苏省麻醉与镇痛应用技术重点实验室,徐州,221002 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的:观察不同缺氧时间对小鼠即时痛阈的影响.方法:受试小鼠80只随机分为缺氧2、4、6、8min组,每组20只(其中10只接受热板法实验,另外10只接受甩尾法实验),观察不同缺氧时间对小鼠即时热板法痛阈(pain threshold in hot-plate test,HPPT)和甩尾潜伏期(the tail-flick la-tency,TFL)的影响.结果:热板法实验提示:与各组基础HPPT相比,缺氧2min组和缺氧4min组小鼠的即时HPPT均降低(P<0.05);缺氧6min组和缺氧8min组小鼠的即时HPPT均增加(P<0.05).甩尾法实验提示:与各组基础TFL相比,缺氧2min组小鼠的即时TFL差异无统计学意义(P>0.05);缺氧4min组小鼠的即时TFL缩短(P<0.05);缺氧6min组和缺氧8min组小鼠的即时TFL均明显延长(P<0.01).结论:随着缺氧时间的增加,小鼠缺氧后的即时痛阈呈现先降低后增加的变化. |
| 关 键 词： | 缺氧 小鼠 痛阈 |
EFFECTS OF DIFFERENT HYPOXIC TIME ON THE HEAT-INDUCED PAIN THRESHOLD OF MICE |
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| WANG Wen,WEI Jing-Jing,WE Ting-Ting,WANG Xiao-Juan,XIE Yun,ZHAO Jia-Jia,HUANG Hui,MA Gao-Lei,ZHANG Li-Cai. EFFECTS OF DIFFERENT HYPOXIC TIME ON THE HEAT-INDUCED PAIN THRESHOLD OF MICE[J]. Chinese Journal of Pain Medicine, 2011, 17(7). DOI: 10.3969/j.issn.1006-9852.2011.07.012 | |
| Authors: | WANG Wen WEI Jing-Jing WE Ting-Ting WANG Xiao-Juan XIE Yun ZHAO Jia-Jia HUANG Hui MA Gao-Lei ZHANG Li-Cai |
| Affiliation: | WANG Wen1,WEI Jing-Jing1,WU Ting-Ting1,WANG Xiao-Juan1,XIE Yun1,ZHAO Jia-Jia1,HUANG Hui2,MA Gao-Lei3,ZHANG Li-Cai1,4(Department of Anesthesiology,Xuzhou Medical College,Xuzhou 221002) |
| Abstract: | Objective: To observe the effects of different hypoxic time on the immediate pain threshold of mice.Methods: 80 mice were divided into 4 groups: hypoxic period of 2,4,6,8min.Each group had 20 mice with 10 using hot-plate test and other 10 using tail-flick test.Pain threshold in hot-plate test(HPPT) and the tail-flick latency(TFL) were observed.Results: Compared with their former HPPT,immediate HPPT of mice were declined in hypoxic groups of 2 and 4min(P<0.05) and increased in hypoxic groups of 6 and 8min(P<... |
| Keywords: | Hypoxia Mice Pain threshold |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |