叶酸对老年H型高血压病患者血清同型半胱氨酸水平及血压的影响研究

目的：探讨叶酸治疗老年 H 型高血压（HBP）患者时对 BP 值和血清同型半胱氨酸（HCY）水平的影响。方法：本次实验对象共计病例数为150例,均为2014年11月～2015年11月间收治的老年 H 型 HBP 患者,按照数字双盲分配方法以1：1比例将150例患者分为2组,即对照组（CG 组=75例）制定科学的饮食-作息方案,同时给予常规降压治疗;观察组（OG 组=75例）在 CG 组基础上使用叶酸进行治疗,2组患者均持续治疗0.5年,采用血压检测仪和循环酶法实时检测患者 BP 值、HCY 值的变化情况。结果：治疗前 CG 组、OG 组患者 BP 值和 HCY 值差异无统计学意义;6M 后两组患者的2种指标均显著改善,CG 组 HCY 值平均下降（1.70±0.33）umol/L,OG 组下降（6.22±0.40）umol/L,BP 值 OG 组患者下降幅度同样高于 CG 组,两组数据对比差异显著。结论：叶酸药效温和、安全性高,在治疗老年 H 型高血压时能够更高效的降低患者的 BP 值和 HCY 含量,因此值得普及使用。

Effect of folic acid on serum homocysteine and blood pressure in elderly patients with type H hypertension

Objective To investigate the effects of folic acid on BP and serum homocysteine (HCY) levels in elderly patients with type H hypertension (HBP). Methods The object of the experiment, total number of cases for 150 cases were admitted in our hospital between november november 2014 and 2015 elderly H-type HBP patients, according to the number of double-blind allocation method in a 1: 1 ratio will be 150 patients divided into 2 groups, control group (CG=75 cases) to formulate a scientific diet routine scheme, while giving conventional antihypertensive therapy; observation group (OG group 75 cases) in CG group based on the use of folic acid treatment, 2 groups of patients continued treatment 0.5 years, the instrument for measur-ing blood pressure and circulating enzymatic method for real-time detection of BP patients value, Hcy value changes. Results Before treatment, CG group, the og group of patients with BP values and Hcy values were not statistically significant.6m, two in-dexes of two groups of patients were significantly improved, CG Hcy value dropped by an average of (1.70+0.33) umol / L, the og group decreased (6.22+0.40) umol / L, BP values og patients decline was higher than that in CG group, the differences between the data of two groups of P > 0.05. Conclusion Folic acid is effective and safe in the treatment of elderly patients with type H, it can be more efficient to reduce the patient’s BP and HCY content, so it is worth popularizing.