| 基质金属蛋白酶-2、3及其组织抑制剂TIMP-1在子宫内膜异位症中的表达 |
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| 引用本文： | 刘海英,于晓艳,傅松滨,关咏梅.基质金属蛋白酶-2、3及其组织抑制剂TIMP-1在子宫内膜异位症中的表达[J].中国优生与遗传杂志,2005,13(12):19-20. |
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| 作者姓名： | 刘海英 于晓艳 傅松滨 关咏梅 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院,哈尔滨,150086
2. 哈尔滨医科大学遗传教研室 |
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| 摘 要： | 目的探讨基质金属蛋白酶(MMP-2、MMP-3)及其抑制剂(TIMP-1)在子宫内膜异位症发生及发展中的作用.方法采用免疫组化SP法分别测定MMP-2、MMP-3 、TIMP-1在卵巢子宫内膜异位症异位内膜60例(A组),子宫腺肌症异位内膜40例(B组),子宫肌瘤子宫内膜30例(对照组C)的表达强度.结果 A、B组中MMP-2、MMP-3的表达强度明显高于对照组(P<0.05)而TIMP-1的表达明显低于对照组(P<0.05);A、B组间MMP-2、MMP-3 、TIMP-1 的表达无明显差异(P>0.05).结论在子宫内膜异位症中MMP-2、MMP-3的过度表达及TIMP-1的低表达可能与内异症的发生与发展有关.
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| 关 键 词： | 子宫内膜异位症 基质金属蛋白酶 基质金属蛋白酶组织抑制剂 |
| 文章编号： | 1006-9534（2005）12-0019-02 |
| 收稿时间： | 2005-09-02 |
| 修稿时间： | 2005年9月2日 |
The expression of matrix metallop roteinase-2,3 and tissue inhibitor of metalloproteinase-1 in endometriosis |
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| LIU Hai-ying,YU Xiao-yan,FU Song-bin,GUAN Yong-mei.The expression of matrix metallop roteinase-2,3 and tissue inhibitor of metalloproteinase-1 in endometriosis[J].Chinese Journal of Birth Health & Heredity,2005,13(12):19-20. |
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| Authors: | LIU Hai-ying YU Xiao-yan FU Song-bin GUAN Yong-mei |
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| Institution: | 1. Department of Obstetrics and Cynecology, Second Hospital of Harbin Medical University, Harbin China 150086; 2. Laboratory of Medical Genetics, Harbin Medical University, Harbin China 150086 |
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| Abstract: | Objective: To investigate the role of matrix metalloproteinase-2,3 and tissue inhibitor of metalloproteinase-1 in the pathogenesis endometriosis.Methods:Immunohistochemical method(SP) was employed to detect the expression of MMP2,3 and TIMP-1 in ectopic endometriotic tissue from women with endometriosis(60 cases) and with adenomyosis(40 cases) and the normal controls(30 cases).Results:The expressions of MMP-2,MMP-3 in ectopic endometriotic tissue were higher than those of uterine endometrium from women without endometrosis(P<0.05).The expression of TIMP-1 in ectopic endometriotic tissue were lower than those of uterine endometrium from women without endometrosis(P<0.05).The expressions of MMP2,MMP-3,TIMP-1 were no obvious difference between the ectopic endometriotic tissue from women with endometriosis and with adenomyosis(P>0.05).Conclusion:The increased expression of MMP-2,3 and decrease expression of TIMP-1 in the ectopic endometriotic tissue contributes to the pathogenosis of endometriosis. |
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| Keywords: | Endometriosis Matrix metalloproteinase Tissue inhibitor of metalloproteinase |
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