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| 《圣济总录》芎附汤急性毒性实验 | |
| 引用本文： | 郭炜,韩涛. 《圣济总录》芎附汤急性毒性实验[J]. 辽宁中医药大学学报, 2012, 0(7): 44-45 |
| 作者姓名： | 郭炜 韩涛 |
| 作者单位： | 山东中医药大学 |
| 基金项目： | 国家“重大新药创制”关键技术项目(2009ZX09502-015) |
| 摘 要： | 目的:通过动物实验判断芎附汤的急性毒性,为临床用药提供安全依据。方法:给予小鼠灌胃芎附汤,通过预实验测定半数致死量(LD50),并据此测定最大耐受量(MTD)。结果:急性毒性实验未能测出LD50,改测最大耐受量为240g/kg,相当于临床人用量的243倍。结论:芎附汤是安全有效的药物,可以在临床使用。 |
| 关 键 词： | 芎附汤 急性毒性实验 最大耐受量 半数致死量 |
Acute Toxicity Test of Xiongfu Decoction |
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| GUO Wei,HAN Tao. Acute Toxicity Test of Xiongfu Decoction[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2012, 0(7): 44-45 | |
| Authors: | GUO Wei HAN Tao |
| Affiliation: | (Shandong University of Traditional Chinese Medicine,Ji’nan 250355,Shandong,China) |
| Abstract: | Objective:Through animal experiments to determine the acute toxicity of Xiongfu Decoction,it provides a safe basis for clinical use.Method:Firstly judge the possibilities of determined half lethal dose(LD50)by the pre-experiment,and determine LD50 or the maximum tolerated dose(MTD).Result:Acute toxicity test can’t measure the LD50.The largest dose(MTD)was 240g·kg-1,equivalent to clinical dose by 243 times.Conclusion:Xiongfu Decoction is safe and reliable and can be used in clinic. |
| Keywords: | Xiongfu Decoction acute toxicity test the largest dosage(MTD)of the determination LD50 |
| 本文献已被 CNKI 等数据库收录！ | |