磁共振扩散加权成像对人脑正常ADCav值的测量及定量分析

目的:对不同年龄组正常人脑进行水分子扩散加权成像,探讨年龄因素对正常人脑白质及灰质核团ADCav值的影响,为进一步研究放射性脑损伤提供不同年龄段ADCav正常值范围。方法:研究样本60例,分为<60岁和≥60岁两个年龄组,进行脑水分子扩散加权成像,并分别测量额叶和枕叶白质ADC值作为皮质下白质的代表,测量丘脑ADC值作为灰质团块的代表。结果:年龄<60岁组脑白质的ADCav值为(0.70±0.07)×10-3mm2/s,丘脑的ADCav值为(0.83±0.08)×10-3mm2/s;年龄≥60岁组脑白质的ADCav值为(0.73±0.10)×10-3mm2/s,丘脑的ADCav值为(0.84±0.06)×10-3mm2/s。两年龄组脑白质间差异具有统计学意义(P<0.05),丘脑间无统计学意义,白质和丘脑间有显著性差异(P<0.001)。结论:①伴随年龄的增长,正常脑白质ADC值呈现微弱的增长趋势,尤其是60岁以上老年人ADC值的增长趋势更为明显;②定量的ADC值分析对疾病的早期诊断及检测病变的发生、发展都有重要的意义;③临床研究中在对照样本的选取上应注意年龄因素的影响,本研究所得数据可作为进一步研究的正常参考值。

The measurement and quantitative analysis of ADCav value with MR diffusion-weighted imaging in normal hu-man brain

Objective:Diffusion-weighted imaging(DWI) was performed in normal brain of different age group.The aim of this study was to evaluate the influence upon ADCav value of white and grey matter due to age factor and to provide a range of normal values for radioencephalopathy.Methods: Sixty cases were divided into two age groups: ≥60 yrs and <60 yrs.DWI was performed and ADCav value were measured on white and grey matter respectively.Results: The ADCav value of white matter was(0.70±0.07)×10~(-3)mm~2/s in age<60 yrs group and(0.73±0.10)×10~(-3)mm~2/s in age≥60yrs group.The ADCav value of thalamus was(0.83±0.08)×10~(-3)mm~2/s in age<60yrs group and(0.84±0.06)×10~(-3)mm~2/s in age≥60yrs group.Prominent positive correlation was present between two age groups in alba(P<0.05),and between alba and thalamus(P<0.001).Conclusion: ① To follow age growth,ADC value of normal alba presented tenuous increasing tendency especially the people aged≥60yrs.② ADCav value analysis has important significance in early diagnosis,occurrence and development of diseases.③ In clinical research,we ought to pay attention to the influence of age factor while select control group.Income data of this study can take as normal reference value in other more study.