微量泵静脉注射异舒吉和硝酸甘油治疗高血压急症的疗效比较

目的：比较经微量泵静脉注射异舒吉和硝酸甘油治疗高血压急症的疗效和安全性。方法：选择高血压急症患者72例，随机分为异舒吉组（A组35例）和硝酸甘油组（B组37例）。A组应用异舒吉50 ml（50 mg，3～15 ml/h）直接静脉泵入；B组应用硝酸甘油50 mg加入40 ml生理盐水静脉泵入（2～10 ml/h）；两组患者均根据血压调整注射剂量，并观察用药前后血压及心率的不良反应。结果：两组疗效无显著差异。B组治疗后较治疗前心率明显加快，不良反应的发生率明显高于A组。结论：异舒吉治疗高血压急症的临床疗效与硝酸甘油一致,但不良反应少，安全性高，若条件允许可作为首选。

The comparative effectiveness research on Isoket and nitroglycerin by intravenous pumping in the treatment of hypertensive emergency

Objective： To investigate the effect of Isoket and nitroglycerin by intravenous pumping in the treatment of hypertensive emergency. Methods：Seventy two cases of hypertensive emergency were randomly divided into group A（35 cases） and group B（37 cases）. Isoket（50 mg） were applied by intravenous pumping in group A, nitroglycerin（50 mg） were applied by intravenous pumping in group B. Blood pressure, heart rate, adverse reactions were measured at before and 15 min,30 min and 60min after treatment. Results： The effective rate of the two groups in the treatment of hypertensive emergency had no significant difference. The hate rate of group B was faster after treatment. The incidence rate of adverse reactions in group B was higher than group A. Conclusion：The curative effect of Isoket in the treatment of hypertensive emergency is the same as nitroglycerin. It is safe and effective, thereby worthy of clinical promotion.