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Effect of treatment with interferon α-2b and ribavirin in patients infected with genotype 2 hepatitis C virus |
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| Authors: | Yoshihiko Nagase Hiroshi Yotsuyanagi Chiaki Okuse Kiyomi Yasuda Tomohiro Kato Kazuhiko Koike Michihiro Suzuki Kusuki Nishioka Shiro Iino Fumio Itoh |
| Affiliation: | Department of Internal Medicine, Division of Gastroenterology and Hepatology and;Department of Bioregulation and Proteomics, St. Marianna University, Kawasaki,;Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo and;Center for Liver Diseases, Kiyokawa Hospital, Tokyo, Japan |
| Abstract: | Aim: Nearly 20% of chronic hepatitis C (CHC) patients with genotype 2 hepatitis C virus (HCV) infection are not curable, even by interferon (IFN)–ribavirin combination therapy. The aim of this study is to investigate the factors that determine the efficacy of combination therapy in patients with genotype 2 HCV infection. Methods: Fifty patients with CHC who underwent a treatment of 6 MU IFN α-2b with ribavirin for 24 weeks were retrospectively analyzed. Results: All the patients showed no serum HCV-RNA within 12 weeks after starting the therapy. Forty-one of the 50 patients (82%) achieved a sustained virological response (SVR). The age, sex, genotype (2a vs. 2b) and grade/stage of the liver by histopathology and pretreatment viral load werenot different between the sustained responders and relapsers. Univariate analysis showed that an earlier viral clearance from blood and a larger number of amino acid substitutions in the interferon sensitivity determining region (ISDR) were predictors of SVR. Multivariate analysis showed that a large number of amino acid substitutions in the ISDR was a predictor of SVR. Conclusion: The characterization of the amino acid sequences of ISDR may be helpful for predicting a relapse after combination therapy in patients with genotype 2 HCV infection. |
| Keywords: | genotype hepatitis C virus interferon ISDR ribavirin |