| 护胃散对小鼠的急性毒性及胃排空的影响 |
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| 引用本文： | Wang Rui,王瑞,闫荟,胡燕君,钟蕾,王苏会,李红磊,潘宏伟,赵汉臣. 护胃散对小鼠的急性毒性及胃排空的影响[J]. 中国药师, 2008, 11(10) |
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| 作者姓名： | Wang Rui 王瑞 闫荟 胡燕君 钟蕾 王苏会 李红磊 潘宏伟 赵汉臣 |
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| 作者单位： | 1. 北京军区总医院药剂科,北京,100700
2. 解放军总后勤部第1门诊部 |
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| 摘 要： | 目的：观察护胃散对小鼠的急性毒性及其对胃排空的影响。方法：以灌胃给药的方式评价护胃散的急性毒性对小鼠胃排空的影响，对阿托品引起胃排空减慢的影响以及对甲氧氯普胺引起胃排空加快的影响。结果：给药后，小鼠在饮食、活动、精神状态等体征方面均无异常变化，体重变化也在正常范围内（P〉0．05）。经尸检，主要脏器未见明显病理变化。护胃散可促进正常小鼠胃排空，并可抑制硫酸阿托品引起的胃排空减慢，但对甲氧氯普胺引起的胃排空加快无明显影响。结论：护胃散对小鼠胃排空有促进作用，且无明显毒性，提示其在临床规定剂量范围内应用是安全的。
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| 关 键 词： | 护胃散 急性毒性实验 实验动物 胃排空 |
Effects of Huwei Powder on Acute Toxicity and Gastric Emptying in Jimpy Mice |
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| Wang Rui. Effects of Huwei Powder on Acute Toxicity and Gastric Emptying in Jimpy Mice[J]. China Pharmacist, 2008, 11(10) |
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| Authors: | Wang Rui |
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| Affiliation: | Wang Rui~1 Yan Hui~1 Hu Yanjun~2 Zhong Lei~1 Wang Suhui~1 Li Honglei~2 Pan Hongwei~1 Zhao Hanchen~1(1.Department of Pharmacy,General Hospital of Beijing Military Comm,,Beijing 100700,China,2.First Clinic Department of GLD of PLA) |
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| Abstract: | Objective:To observe the effect of Huwei powder on acute toxicity and gastric emptying in Jimpy mice. Method:Jimpy mice were assigned to receive Huwei powder.Then the acute toxicity,normal gastric emptying,faster gastric emptying induced by metoclopramide,slower gastric emptying induced by atropine sulfate were measured.Result:Jimpy mice had no abnormal changes in bite and sup,activity,psychosis,coat and skin,urine and faeces.There were also no significant changes in body weight (P>0.05).All important organ... |
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| Keywords: | Huwei powder Acute toxicity trial Laboratory animals Gastric emptying |
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