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| 马兜铃酸I药动学研究进展 | |
| 引用本文： | 王冠,王智民,孙启时. 马兜铃酸I药动学研究进展[J]. 中国中药杂志, 2006, 31(19): 1573-1575 |
| 作者姓名： | 王冠 王智民 孙启时 |
| 作者单位： | 沈阳药科大学中药学院，中国中医科学院中药研究所，沈阳药科大学中药学院 辽宁沈阳110016，中国中医科学院中药研究所，北京100700，北京100700，辽宁沈阳110016 |
| 摘 要： | 马兜铃酸I在体内吸收迅速,分布迅速,大多数实验表明其体内分布呈一室模型,少量实验呈二室模型,马兜铃酸I的消除与其给药剂量有关,低剂量组消除较快,高剂量组消除较慢。马兜铃酸I药动学特征可能决定了其蓄积毒性的产生。 |
| 关 键 词： | 马兜铃酸I 药动学 |
| 收稿时间： | 2006-06-11 |
Advances in studies on pharmacokinetics of aristolochic acid I |
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| WANG Guan ; WANG Zhi-min ; SUN Qi-shi. Advances in studies on pharmacokinetics of aristolochic acid I[J]. China Journal of Chinese Materia Medica, 2006, 31(19): 1573-1575 | |
| Authors: | WANG Guan WANG Zhi-min SUN Qi-shi |
| Abstract: | Aristolochic acid I(AA-I) was absorbed and distributed quickly in vivo,the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model,respectively.The elimination of AA-I has relationship with the dosage,the low dose group eliminates more quickly than the high dose group.The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera. |
| Keywords: | aristolochic acid I pharmacokinetic |
| 本文献已被 CNKI 等数据库收录！ | |