Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis |
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| Authors: | Wei Shi Jiangfeng Hu Shizhang Zhu Xiaoying Shen Xiaoyan Zhang Changqing Yang Hengjun Gao Hao Zhang |
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| Affiliation: | 1Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China;2Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai 200065, China;3National Engineering Center for Biochip at Shanghai, Shanghai 201203, China |
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| Abstract: | ![]()
The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis. |
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| Keywords: | MTA2 Ki-67 HCC liver cancer |
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