乳腺炎性肌纤维母细胞瘤临床病理观察

目的 探讨乳腺炎性肌纤维母细胞瘤的临床病理特征和鉴别诊断.方法 对1例乳腺炎性肌纤维母细胞瘤进行临床、组织学和免疫组化观察,并复习相关文献.结果 患者女性,62岁.左乳腺扪及一肿块8个月,边界尚清.组织学显示,黏液背景下瘤细胞以梭形细胞为主,细胞无异型性,核分裂象少见.间质内见大量淋巴细胞,浆细胞浸润,血管丰富,局部有胶原化.免疫组化:梭形细胞vimentin中等(+),SMA、actin和ALK(+)；CK、34βE12、S-100、myogenin、MBP和CD34(-).结论 炎性肌纤维母细胞瘤是一种特殊类型的间叶性肿瘤,罕见于乳腺,应与梭形细胞癌、纤维瘤病、瘢痕、结节性筋膜炎等相鉴别.

Inflammatory myofibroblastic tumor of the breast:a clinicopathologic observation

Objective To investigate the clinicopatholoical features and differential diagnosis of inflammatory myofibroblastic tumor(IMT) in breast.Methods A case of IMT in breast was studied with histology and immunohistochemistry,followed by discussion through review of literature.Results Female patients complained of a mass located in her left breast,and the tumor was well circumscribed.Microscopically,the lesion was composed mainly of spindle tumor cells in a myxoid and collagenous background with abundant blood vessels and an infiltration of lymphocytes and plasma cells.The spindle cells was no atypia and mitosis was scarce.The tumor cells were immunoreactive to vimentin,SMA,actin,ALK,but negative for CK,34βE12,S-100,MBP,myogenin,and CD34.Conclusions IMT is a special type of soft tissue tumor and occurs rarely in breast.More attention should be paid in the differential diagnosis of this tumor from spindle cell carcinoma,fibromatosis,scar and nodular fasciitis.