| HBV感染与宿主基因及病毒DNA甲基化 |
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| 引用本文： | 张敏洁,陈维顺. HBV感染与宿主基因及病毒DNA甲基化[J]. 医学综述, 2012, 0(19): 3181-3183 |
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| 作者姓名： | 张敏洁 陈维顺 |
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| 作者单位： | 中南大学湘雅医学院株洲临床学院株洲市一医院消化内科 |
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| 摘 要： | 乙型肝炎病毒(HBV)感染是慢性肝炎、肝硬化及肝癌的重要病因,HBV感染诱导的宿主基因组甲基化及病毒自身DNA甲基化改变可能是病毒感染慢性化及慢性肝病形成的重要发病机制之一,HBV基因组及HBV共价闭合环状DNA的甲基化在调控病毒复制和蛋白表达中起着重要作用。探讨HBV DNA甲基化对于研究病毒的致病机制、指导HBV感染的治疗有重要意义。
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| 关 键 词： | 乙型肝炎病毒 DNA甲基化 HBV共价闭合环状DNA甲基化 |
HBV Infection and Methylation of Host and Viral Genome |
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| ZHANG Min-jie,CHEN Wei-shun. HBV Infection and Methylation of Host and Viral Genome[J]. Medical Recapitulate, 2012, 0(19): 3181-3183 |
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| Authors: | ZHANG Min-jie CHEN Wei-shun |
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| Affiliation: | .(Zhuzhou Clinical Hospital of Xiangya Medical College,Central South University;Department of Gastroenterology,Zhuzhou First Hospital,Zhuzhou 412000,China) |
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| Abstract: | Hepatitis B virus(HBV)infection is a major cause of chronic hepatitis,cirrhosis,and development of hepatocellular carcinoma(HCC).Methylation of host genome and HBV DNA induced by HBV infection may be one of the major pathogenesis leading to persistent virus infection and cause chronic liver disease.Methylation of HBV and covalently closed circular DNA(HBV cccDNA)plays an important role in regulation of viral replication and protein expression.Discussion of methylation of HBV is of great importance for the research of pathogenic mechanism and guiding HBV infection treatment. |
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| Keywords: | Hepatitis B virus DNA methylation Methylation of HBV cccDNA |
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