丙戊酸镁预防治疗躁狂症的疗效观察

目的:探讨丙戊酸镁预防治疗躁狂症的临床疗效及安全性。方法:随机将68例躁狂症患者分为对照组(碳酸锂)和观察组(碳酸锂治疗基础上,加用丙戊酸镁缓释片),每组各34例,治疗2个月,根据倍克-拉范森躁狂量表(BRMS)减分率,评估和比较两组患者临床疗效,观察治疗前后两组患者BRMS评分变化情况及治疗期间不良反应。结果:与对照组相比,观察组患者总有效率明显升高,BRMS评分明显降低,均P<0.05。治疗期间,两组患者都没有出现严重不良反应。结论:丙戊酸镁能够较好地防治躁狂症,并且不良反应少,具有较高的治疗安全性,值得临床推广。

Efficacy observation of magnesium valproate in prevention and treatment of mania

Objective： To study clinical efficacy and safety of magnesium valproate in prevention and treatment for mania. Methods：68 patients with mania in our hospital were randomized into control group （34 cases, taking lithium carbonate） and observa-tion group （34 cases, taking magnesium valproate sustained-release tablets based on lithium carbonate）, and they were treated for 2 months. The clinical efficacy were evaluated and compared in the two groups according to Bech-Rafaelsen mania rating scale （ BRMS） reduction rate. The changes of BRMS scores and adverse reactions in the two group during the treatment period were observed. Re-sults：Compared with control group, the total effective rate in observation group was significantly increased （P〈0. 05）; The BRMS score after the treatment was obviously reduced （P〈0. 05）. There were no serious adverse reactions during the treatment period in the two groups. Conclusions：Magnesium valproate can better prevent and treat mania with less adverse reactions and high safety, and is worthy of clinical promotion.