MT1-MMP 在乳腺癌中表达的研究

目的：探讨膜型基质金属蛋白酶-1（MT1-MMP）表达与乳腺癌临床病理因素的关系。方法用免疫组化法检测69例乳腺癌组织及27例正常乳腺组织中MT1-MMP的表达水平，分析其与乳腺癌临床分期、淋巴结转移和器官转移的相关性。结果MT1-MMP蛋白在69例乳腺癌组织中阳性表达61例（88．4％），在27例正常乳腺组织中无一例阳性表达（P＜0．01）；在T1＋T2与T3＋T4两组阳性表达为24例（77．4％）和37例（97．4％）（P＜0．05）；在N0＋N1与N2＋N3两组阳性表达为14例（70％）和47例（95．9％）（P＜0．01）；在M0与M1两组阳性表达为39例（82．98％）和22例（100％）（P＜0．05）。结论MT1-MMP蛋白参与了乳腺癌的浸润生长和扩散转移过程，是乳腺癌发生发展中的重要生物学事件。

STUDY ON THE EXPRESSION OF MT 1-MMP IN BREAST CANCER

ObjectiveTo investigate the membrane type matrix metalloproteinase -1 （MT1-MMP） ex-pression and clinicopathological factors of breast cancer .MethodsThe expression of MT1-MMP was detec-ted by immunohistochemical method in 69 cases of breast carcinoma and 27 cases of normal breast tissues , analyze its correlation with clinical stage ,lymph node metastasis of breast cancer and metastasis .Re-sultsThe positive expression of MT1-MMP protein in 69 cases of breast cancer in 61 cases （88 .4% ） ,there were no positive expression in 27 cases of normal breast tissue （ P 〈0 .01）;in the T1＋ T2 and T3＋ T4 two positive expression in 24 cases （77 .4% ） and 37 cases （97 .4% ） （ P〈0 .05）;in N0＋N1 and N2＋N3 two positive expression in 14 cases （70% ） and 47 cases （95 .9% ） （ P〈0 .01）;in the M0 and M1 two posi-tive expression in 39 cases （82 .98% ） and 22 cases （100% ） （ P 〈0 .05） .ConclusionMT1-MMP protein is involved in breast cancer invasion and spread process ,is an important biological events in the development of breast cancer .