| 蛇葡萄根的保肝降酶及抗自由基损伤作用 |
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| 引用本文： | 张秀明,陈科力,李翰明.蛇葡萄根的保肝降酶及抗自由基损伤作用[J].中国药师,1999,2(5):225-226. |
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| 作者姓名： | 张秀明 陈科力 李翰明 |
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| 作者单位： | 湖北中医学院，湖北中医学院药学系，湖北中医学院药学系，湖北中医学院药学系，荆州市第一人民医院 97级研究生，武汉 430061，武汉 430061，武汉 430061 |
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| 摘 要： | 用D-氨基半乳糖(D-GalN)制备大鼠急性肝损伤模型,检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察肝组织病理变化,以探讨中药蛇葡萄根对急性肝损害的保护作用。结果显示:蛇葡萄很能显著降低血清ALT、AST含量,提高SOD含量,降低MDA含量,高剂量组还能减轻肝细胞受损程度。提示蛇葡萄根具有保肝降酶及抗自由基损伤作用。
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| 关 键 词： | 蛇葡萄 D-氨基半乳糖 急性肝损伤 |
Effects of the Root of Ampelopsis Sinica on Protecting Liver, Reducing Enzymes, and Resisting Free Radicle Injury |
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| Zhang Xiuming Chen Keli,Li Hanmin,Zhang ChizhiHubei College of T. C. M,Wuhan,P. R. China Graduate student of grade,in Hubei College of T. C. M..Effects of the Root of Ampelopsis Sinica on Protecting Liver, Reducing Enzymes, and Resisting Free Radicle Injury[J].China Pharmacist,1999,2(5):225-226. |
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| Authors: | Zhang Xiuming Chen Keli Li Hanmin Zhang ChizhiHubei College of T C M Wuhan P R China Graduate student of grade in Hubei College of T C M |
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| Institution: | Zhang Xiuming* Chen Keli,Li Hanmin,Zhang ChizhiHubei College of T. C. M,Wuhan,430061,P. R. China* Graduate student of grade 97,in Hubei College of T. C. M. |
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| Abstract: | Acute hepatic injury model of rats were induced by D-GalN. The ALT, AST in serum and SOD, MDA in liver homogenate were detected. Changes of histopathology were observed. The results showed that the extract of roots of Ampelopsis sinica could reduce serum levels of ALT, AST; raise SOD and reduce MDA in liver homogenate; promote revision of injuried liver cells to some extent. We concluded that the root the multiple roles of Ampelopsis sinica showed the multiple roles of protecting liver, reducing enzymes and resisting free radicle injury. |
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| Keywords: | Ampelopsis sinica D-GalN Acute hepatic injury |
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