层粘连蛋白受体及微血管密度与甲状腺癌转移的关系

目的　探讨微血管密度 (MVD)层粘连蛋白受体(L N- R)表达水平及其与甲状腺癌转移的关系。方法　采用免疫组织化学 SP法检测 33例原发性甲状腺癌中 L N - R的表达及 MVD计数。结果　 33例原发性甲状腺癌中 L N- R表达阳性者 19例 ,表达率为 5 7.6 %。在有转移的 14例甲状腺癌中 12例 L N - R表达阳性 ,表达率为 85 .7%。在无转移的19例中 ,L N- R表达阳性者 7例 ,表达率为 36 .8%。在有转移的甲状腺癌中 L N- R阳性表达率明显高于无转移的甲状腺癌 (P<0 .0 0 1)。MVD计数在有淋巴结转移的甲状腺癌中为 88.6 9± 18.2 6 ,在无转移的甲状腺癌中为 31.18± 14.42 ,后者 MVD计数明显低于前者 (P<0 .0 0 1)。在无淋巴结转移的甲状腺癌中 L N- R表达阳性者的 MVD计数为 43.16±10 .71,明显高于 L N- R表达阴性者 (P<0 .0 5 )。结论　 L N- R表达及 MVD计数与甲状腺癌的侵袭转移有关 ,可作为甲状腺癌患者的预后指标

THE SIGNIFICANCE OF MICROVESSEL DENSITY AND LAMININ RECEPTOR EXPRESSION IN THYROID CARCINOMA

Objective To investigate the relationship between the laminin receptor expression and the microvessel density with metastasis of thyroid carcinoma. Methods The SP immunohistochemical method was employed to determine LN R expression level and microvessel count in 33 cases of primary thyroid carcinoma. Results The overall positive rate of LN L expression in thyroid carcinoma was 57 6 % (19/33), among which the node positive and negative groups were 85 7 % and 36 8 % respectively ( P <0 01). On the other hand, microvessel density (MVD) of the node positive and negative groups were 88 69, 18 26 and 31 18, 14 42 respectively ( P <0 001). In the node negative group, if the LN R expression was positive MVD was higher than that of LN R expression negative group. Conclusion Since the LN R expression and MVD show a positive correlation with invasion and metastasis of thyroid carinoma. They were considered to be an important prognostic indicator of thyroid cancer.