胃腺癌中P TEN 的表达与IGF ⅠR 的相关性

 目的　研究抑癌基因PTEN 和胰岛素样生长因子Ⅰ受体( IGF ⅠR) 在胃腺癌组织中的表达,探 讨PTEN 与IGF ⅠR 的相关性及其与胃癌临床病理学特征的关系。方法　采用免疫组织化学SP 法检 测60 例胃腺癌患者肿瘤组织和癌旁正常组织中PTEN 和IGF ⅠR 的表达水平。结果　60 例胃腺癌组 织中PTEN 蛋白表达阳性率仅为41. 7 % ,明显低于癌旁正常组织,两者差异有统计学意义( P = 0. 001) ; 其表达水平与年龄、性别无关( P > 0. 05) ,与分化程度( P = 0. 009) 、肿瘤浸润程度( P = 0. 001) 、淋巴结转 移( P = 0. 004) 和临床分期( P = 0. 002) 显著相关;在胃腺癌组织中IGF ⅠR 和PTEN 蛋白表达之间呈明 显负相关( rs = - 0. 469 P < 0. 001) 。结论　抑癌基因PTEN 的失活与胃癌的生物学行为密切相关; PTEN 可能对IGF ⅠR 的表达有着调控作用,联合检测两者可作为胃癌诊断、治疗和预后判断的参考指 标。

Expression and Relativity between Tumor Suppressor Gene PTEN and IGF I R in Gastric Adenocarcinoma

Objective 　To study the expression between tumor suppressor gene PTEN and IGF ⅠR in gas2 t ric adenocarcinoma , and to investigate the relationship between PTEN and IGF ⅠR and their connection with clinical pathological characteristics. Methods 　The expression level of PTEN and ICF ⅠR was de2 tected by immunohisto chemical SP technique in tumor and adjacent normal tissues of 60 patient s with gast ric adenocarcinoma. Results 　The positive rate of PTEN in tissues of 60 cases with gast ric adnocarci2 noma was 47. 1 % , which was significantly lower than that in adjacent normal tissues ( P = 0. 001) . The expression level of PTEN had no correlation with age and sex ( P > 0. 05) but it was significantly related to the extent of histological differentiation ( P = 0. 009) , the depth of tumor invasion ( P = 0. 001) , lymph node metastasis ( P = 0. 004) and clinical stage ( P = 0. 002) . There was significantly negative correlation between PTEN and IGF ⅠR expression ( rs = - 0. 469 , P < 0. 001) . Conclusion 　The lost activity of tumor suppressor PTEN was closely related to the biological behavior of carcinoma of stomach. PTEN may cont rol the expression of IGF ⅠR. PTEN and IGF ⅠR can serve as the markers in the diagnosis , t reatment and prognosis of gast ric adenocarcinoma.