女性不孕患者胰岛素抵抗的临床特征研究 |
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引用本文: | 肖宇,黄永刚,侯晓红,吕杰强.女性不孕患者胰岛素抵抗的临床特征研究[J].实用全科医学,2014(1):80-82. |
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作者姓名: | 肖宇 黄永刚 侯晓红 吕杰强 |
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作者单位: | 温州医学院附属第二医院生殖中心, 浙江省温州市325000 |
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摘 要: | 目的 研究不孕妇女中胰岛素抵抗(IR)的分布情况,探讨其与患者临床特征之间的关系.方法 回顾分析907名不孕妇女的糖代谢及基础性激素数据,以空腹胰岛素(FINS)及稳态评估模型(HOMA-IR)评估患者IR状态,分析可能与IR有关的临床特征.结果 取研究人群的FINS、HOMA-IR 75%位点值为生理高限值,FINS≥9.61 mIU/L或HOMA-IR≥2.20者被认为处于IR状态.IR组月经稀发发生率及超重者比例显著高于非IR组(P<0.01),但多囊卵巢综合征(PCOS)发生率相似(P>0.05).IR组基础睾酮(T)值较非IR组显著升高(P<0.05).多元回归分析示IR与BMI、是否超重以及T值有显著联系(P<0.01).结论 月经稀发的不孕女性患者中更易存在IR状态,与是否合并PCOS无关,同时,BMI的增加使IR的发生率更高.
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关 键 词: | 胰岛素抵抗 稳态评估模型 非多囊卵巢综合征 月经稀发 肥胖 |
Clinical characteristics of infertile females with insulin resistance |
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Institution: | XIAO Yu, HUANG Yong-gang, HOU Xiao-hong, et al.( Department of Reproductive Medicine Center, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang, China) |
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Abstract: | Objective To investigate the distribution of insulin resistance (m) in infertile females, and to explore rela- tionships between IR and other clinical characteristics. Methods Nine hundred and seven infertile women were recruited into this retrospective study. Fasting insulin(FINS) and homeostasis model assessment of insulin resistance (HOMA-IR) were used to assess whether these patients were IR or not. Clinical characteristics were compared between IR group and Non-IR group,whose relationships with IR were then analyzed. Results The 75th percentiles of FINS and HOMA-IR were used as cut-off values of IR. FINS〉~9.61 mlU/L or HOMA-IR〉~2.20 was considered to be IR. Incidences of oligo- menorrhea and overweight significantly increased in IR group than in Non-IR( P 〈 0.01 ) , however,the incidence of poly- cystic ovary syndrome (PCOS) was comparable ( P 〉 O. 05 ). The value of testosterone (T) in IR group increased signifi- cantly(P 〈 0.05 ). Multiple regression analysis showed IR was significantly related with BMI (or whether overweight or not) and T( P 〈 0.05 ). Conclusion Oligomenorrheic infertile females may be prone to m, which was aggravated by the increase of BMI,with or without PCOS. |
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Keywords: | Insulin resistance HOMA Non-PCOS Oligomenorrhea Obesity |
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