鼠神经生长因子联合电子温针治疗糖尿病周围神经病变的疗效观察

目的观察鼠神经生长因子联合电子温针治疗糖尿病周围神经病变(Diabetic perineuropathy,DPN)的临床疗效。方法 50例DPN患者随机分为A、B 2组,A组为鼠源性神经生长因子+电子温针治疗组,B组为单纯甲钴胺治疗组,观察两组治疗前后的临床疗效、运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)的改善情况、多伦多临床评分系统(Toronto clinical scoring system,TCSS)的评分情况及不良反应发生情况。结果 A组总有效率为88.00%,高于B组52.00%,差异具有统计学意义(P0.01);2组治疗前后MNCV、SNCV较治疗前均改善,差异有统计学意义(P0.05);治疗后A组改善情况优于B组,差异有统计学意义(P0.05);2组治疗前后TCSS评分均明显降低,差异有统计学意义(P0.01),治疗后A组改善情况优于B组,差异有统计学意义(P0.05)。结论鼠神经生长因子联合电子温针治疗DPN变疗效确切,是治疗DPN的一种较好的方法,值得在临床上推广应用。

Clinical observation of mouse nerve growth factor combining with electronic temperature needle for treatment of diabetic peripheral neuropathy

Objective To observe the efficacy of the mouse nerve growth factor（mNGF） combining with electronic temperature needle in the treatment of diabetic peripheral neuropathy（DPN）. Methods 50 patients with DPN were ran- domly divided into two groups（ A and B group）.A group received NGF＋electronic temperature needle and B group received mecobalamin only.The clinical efficacy,the level of motor nerve conduction velocity（MNCV） and sensory nerve conduction velocity（SNCV） ,the TCSS were observed before and after treatment. Results The efficacy of A group was highter than that of B group（P〈0. 01）. The levels of MNCV and SNCV of A and B group were improved significantly （P〈0. 05）. The nerve conduction velocity of A group was higher than B group （ P〈0.05）, the TCSS of A and B group was decreased after treatment （P〈0. 01） ,especially in A group （P〈0. 05）. Conclusions Mouse nerve growth factor combining with elec- tronic temperature needle is safe and effective in the treatment of DPN.