| 特发性震颤患者双侧丘脑磁共振波谱研究 |
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| 引用本文： | 吴佩军,王骐,李伟,赵文荣,彭屹峰,汤光宇.特发性震颤患者双侧丘脑磁共振波谱研究[J].现代医学,2010,38(2):133-137. |
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| 作者姓名： | 吴佩军 王骐 李伟 赵文荣 彭屹峰 汤光宇 |
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| 作者单位： | 同济大学附属第十人民医院,放射科,上海,200072 |
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| 摘 要： | 目的:应用氢质子磁共振波谱(1H-MRS)成像方法研究特发性震颤(ET)患者双侧丘脑的代谢物变化情况.方法:对14名ET患者和8名健康成人(为对照组)的双侧丘脑进行1H-MRS检查,计算N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)的比值,并对患者采用Fahn-Tolosa-Marin震颤评定量表进行评分.结果:ET患者症状较明显肢体的相关侧丘脑较非相关侧丘脑的NAA/Cr值升高(1.63±0.25 vs 1.56±0.26),ET患者双侧丘脑感兴趣区内NAA/Cr值较对照组双侧丘脑NAA/Cr均值升高(1.63±0.25 vs 1.49±0.35),但差异均无统计学意义(P＞0.05).结论:ET患者双侧丘脑并未发现神经元损伤丢失现象,其在该病发生发展中起到的作用还有待进一步研究.
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| 关 键 词： | 神经元退行性疾病 特发性震颤 丘脑 磁共振波谱 |
Magnetic resonance spectroscopy of the thalamus in essential tremor patients |
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| WU Pei-jun,WANG Qi,LI wei,ZHAO Wen-rong,PENG Yi-feng,TANG Guang-yu.Magnetic resonance spectroscopy of the thalamus in essential tremor patients[J].Modern Medical JOurnal,2010,38(2):133-137. |
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| Authors: | WU Pei-jun WANG Qi LI wei ZHAO Wen-rong PENG Yi-feng TANG Guang-yu |
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| Institution: | WU Pei-jun,WANG Qi,LI wei,ZHAO Wen-rong,PENG Yi-feng,TANG Guang-yu(Department of Radiology,No.10 People\'s Hospital Affiliated to Shanghai Tong Ji University,Shanghai 200072,China) |
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| Abstract: | Objective: To investigate the metabolic alterations in the bilateral thalamus of patients with essential tremor(ET) using magnetic resonance spectroscopy(MRS).Methods: A single voxel proton magnetic resonance spectroscopic imaging(1H-MRS) of the thalamus was bilaterally performed in 14 ET patients and 8 controls to measure the levels of intracellular metabolites,including N-acetyll-aspartate(NAA),total choline(Cho) and total creatine(Cr) in bilateral thalamus.Results: The mean NAA/Cr ratio of contralatera t... |
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| Keywords: | neuronal degenerative disease essential tremor thalamus magnetic resonance spectroscopy |
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