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| 头孢硫脒在大鼠生理药动学模型研究 | |
| 引用本文： | 鲁澄宇,张小娜,陈方,许卫铭,王海燕,吴铁. 头孢硫脒在大鼠生理药动学模型研究[J]. 中国抗生素杂志, 2011, 36(1) |
| 作者姓名： | 鲁澄宇 张小娜 陈方 许卫铭 王海燕 吴铁 |
| 作者单位： | 1. 广东医学院,湛江,524023 2. 广州白云山化学药创新中心,广州,510515 3. 广州白云山制药股份有限公司广州白云山制药总厂,广州,510515 |
| 摘 要： | 目的 建立头孢硫脒在大鼠的生理药代动力学模型.方法 按照血流限速理论,采用Matlab系统构建生理药代动力学模型程序;模型包括血液、心脏、肺、肾脏、肝脏、肠、胃、脾、胰腺、骨骼肌、皮肤、脂肪和甲状腺等生理相关性组织.生理性模型参数归纳自文献,组织-血液平衡分配系数等药物相关系数由实验测定.结果 大鼠经脉给与头孢硫脒200mg/kg后,模型预测的药物浓度与试验观察值符合良好.结论 建立了头孢硫脒在大鼠的生理药代动力学模型. |
| 关 键 词： | 头孢硫脒 生理模型 组织浓度 大鼠 |
Physiologically based pharmacokinetic models of cefathiamidine in rats |
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| Lu Cheng-yu,Zhang Xiao-na,Chen Fang,Xu Wei-ming,Wang Hai-yan,Wu Tie. Physiologically based pharmacokinetic models of cefathiamidine in rats[J]. Chinese Journal of Antibiotics, 2011, 36(1) | |
| Authors: | Lu Cheng-yu Zhang Xiao-na Chen Fang Xu Wei-ming Wang Hai-yan Wu Tie |
| Affiliation: | Lu Cheng-yu1,Zhang Xiao-na2,Chen Fang3,Xu Wei-ming1,Wang Hai-yan1 and Wu Tie1(1 Guangdong Medical College,Zhanjiang 524023,2 Guangzhou Baiyunshan Chemical Pharmaceutics Innovation Center,Guangzhou 510515,3 Guangzhou Baiyunshan Pharmaceutical Co.,Ltd,Guangzhou 510515) |
| Abstract: | Objective To develop physiologically based a pharmacokinetic(PBPK) model for cefathiamidine in rats.Methods A generic PBPK model,built in-house using MATLAB software,was employed for simulation of concentration-time profiles.The PBPK models consisted of pharmacologically relevant tissues(blood,heart,kidney,lung,gut,stomach,spleen,pancreas,liver,bone,muscle,skin,adipose and thymus) and used the assumptions of perfusion-rate limited tissue distribution of cefathiamidine.The required physiologic model paramete... |
| Keywords: | Matlab |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |