| 胃癌及癌旁组织中CD44v6的表达 |
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| 引用本文： | 周云,宗红,徐虹. 胃癌及癌旁组织中CD44v6的表达[J]. 郑州大学学报(医学版), 2002, 37(5): 593-595 |
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| 作者姓名： | 周云 宗红 徐虹 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,郑州,450052;郑州市中心医院,郑州,450007;河南省肿瘤研究所,郑州,450003 |
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| 基金项目： | 河南省科技攻关基金资助项目991170 2 19 |
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| 摘 要： | 目的：探讨CD44v6在胃癌及癌旁组织中的表达规律及其与胃癌发生发展的关系。方法：采用免疫组化S-P法检测CD44v6在胃癌及癌旁组织中的表达。结果：CD44v6在正常胃粘膜无表达;在癌旁组织中仅有少部分呈弱阳性表达;在胃癌组织中CD44v6的阳性表达率为64.4%。并与胃癌的分化程度,浸润深度,淋巴结转移TNM分期相关。结论：CD44v6在胃癌的淋巴结转移及癌细胞的分化过程中起着重要作用。对早期预测癌细胞的转移潜能,判断胃癌的预后具有重要的临床意义。
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| 关 键 词： | 胃肿瘤 肿瘤转移 CD44v6 |
| 修稿时间： | 2002-03-11 |
Expression of CD44v6 in gastric cancer and its adjacent cancer tissues |
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| ZHOU Yun ),ZONG Hong ),XU Hong ) ). Expression of CD44v6 in gastric cancer and its adjacent cancer tissues[J]. Journal of Zhengzhou University(Medical Sciences), 2002, 37(5): 593-595 |
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| Authors: | ZHOU Yun ) ZONG Hong ) XU Hong ) ) |
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| Affiliation: | ZHOU Yun 1),ZONG Hong 2),XU Hong 3) 1)Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)The Central Hospital of Zhengzhou,zhengzhou 450007 3)Henan Tumor Institute,Zhengzhou 450003 |
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| Abstract: | Aim: To study the relationship between the expression of CD44v6 protein and clinical pathological characterizations of gastric cancer and its adjacent cancer tissues.Methods:Immunohistochemistry S P method was used.Results:Immunoreactivity for CD44v6 was not found in normal gastric tissues; in the adjacent cancer tissues, the weak positive rate of CD44v6 was 35%, while in gastric cancer, the positive rate of CD44v6 was 64.4%;the positive rates of CD44v6 was correlated with histological types, depth of invasion, and lymph node metastasis of gastric cancer. Conclusion:These data suggest that the expression of CD44v6 protein may be useful for evaluating biological behavior of gastric cancer. |
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| Keywords: | gastric neoplasm metastasis CD44v6 gene |
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