乙醛脱氢酶1在鼻咽鳞状细胞癌中的表达及其临床意义

目的 研究乙醛脱氢酶1（ALDH1）在鼻咽鳞状细胞癌中的表达及其临床意义.方法 采用免疫组织化学方法检测确诊为鼻咽鳞状细胞癌未行放化疗的120例患者石蜡标本中ALDH1的表达情况.结果 ALDH1在40.0％（48/120）鼻咽鳞状细胞癌患者中呈中、高表达,在癌巢和间质的边缘,尤其在梭形细胞中呈高表达.ALDH1表达与鼻咽原发灶范围（P=0.011）、颈淋巴结转移（P=0.005）、临床分期（P=0.001）相关,而与年龄、性别无关（均P＞0.05）.Kaplan-Merier生存分析和Cox回归分析均表明ALDH1表达与鼻咽鳞状细胞癌患者的临床预后相关,并且ALDH1是鼻咽鳞状细胞癌患者临床预后的独立危险因素（HR=2.056,P＜0.05）.结论 鼻咽鳞状细胞癌ALDH1的表达与患者的临床预后密切相关,是影响其临床预后的危险因素之一.

Expression and clinical significance of aldehyde dehydrogenase 1 in nasopharyngeal squamous carcinoma

Objective To investigate the significance of aldehyde dehydrogenase 1 （ALDH1）expression in appraising the prognosis of nasopharyngeal squamous carcinoma （NPC）.Methods The expression of ALDH1 protein was detected by immunohistochemistry in human specimens obtained from 120 NPC patients without the history of radiotherapy or chemothetapy.Results A relatively high expression of ALDH1 were observed in 40.0 % （48/120） patients of NPC,the expression of ALDH1 in the edge of the cancer nests and stroma,particularly spindle cancer cells were strongly positive.The positive expression of ALDH1 was closely associated with patients＇ nasopharyngeal tumor size （P =0.011）,lymphatic metastasis （P =0.005） and clinic stage （P =0.001）,but not associated with their gender and age （both P 〉 0.05）.The Kaplan-Merier and Cox regression analysis indicated that ALDH 1 closely correlated with clinical progrosis of the patients.It showed that ALDH1 was an independent risk factor which may affect the prognosis of NPC patients.Conclusion The expression of ALDH1 protein closely correlate with clinic outcome of NPC,suggesting that ALDH1 is a risk factor for clinic progrosis of NPC patients.