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Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists
Authors:Email author" target="_blank">Doris?M?BenbrookEmail author  Scott?A?Kamelle  Suresh?B?Guruswamy  Stan?A?Lightfoot  Teresa?L?Rutledge  Natalie?S?Gould  Bethany?N?Hannafon  S?Terence?Dunn  K?Darrell?Berlin
Institution:(1) Departments of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73190;(2) Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73190;(3) Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73190;(4) Department of Chemistry, Oklahoma State University, Stillwater, OK;(5) Department of OB/GYN, University of Oklahoma HSC, 920 Stanton L. Young Blvd., Room WP 2470, Oklahoma City, OK 73104, USA
Abstract:
Keywords:Heteroarotinoids  NCI human tumor cell line panel  ovarian cancer xenografts  apoptosis  differentiation  MUC-1  topical irritancy
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